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Synthesis and characterization of tannic acid-PEG hydrogel via Mitsunobu polymerization

机译：通过Mitsunobu聚合的单宁酸-PEG水凝胶的合成与表征

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摘要

Tannic acid (TA) based materials have received significant interest owing to their broad spectrum of chemical and biological properties. Herein, a novel tannic acid based hydrogel, TA-PEG hydrogel, was synthesized via Mitsunobu polymerization/polycondensation, in which TA and polyethylene glycol (PEG) were simply crosslinked together by ether linkages. This method was performed in one pot, straightforward, metal free and robust, ignoring the strong ionic/hydrophobic interactions between tannic acid and PEG. Bearing catechol and pyrogallol units from TA, TA-PEG hydrogel did not only reduce the silver and gold precursor, but also served as a capping agent and stabilizer for the in situ formed Au and Ag nanoparticles (NPs). Furthermore, the antioxidant activity of the hydrogel was excellent (94%) in the case of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging. TA-PEG hydrogel also showed antibacterial activity against Staphylococcus aureus and Escherichia coli. This work suggested a new method leading to polyphenol based soft materials rather than a complex coacervated microstructure. The resulting TA-PEG hydrogel has potential application in biomedical materials.
机译：由于其广泛的化学和生物学性质，鞣酸（TA）基于的基于兴趣感。在此，通过Mitsunobu聚合/缩聚合成了一种新型鞣酸水凝胶，其中TA和聚乙二醇（PEG）通过醚键简单地交联。该方法在一个罐中进行，直接，金属自由和稳健，忽略了单宁酸和PEG之间的强离子/疏水相互作用。来自Ta的轴承儿茶酚和吡羟基酚单元，TA-PEG水凝胶不仅减少了银和金前体，而且还用作原位形成的Au和Ag纳米颗粒（NPS）的封端剂和稳定剂。此外，水凝胶的抗氧化活性在1,1-二苯基-2-富铬酰基（DPPH）自由基清除的情况下为优异的（94％）。 TA-PEG水凝胶还显示出对金黄色葡萄球菌和大肠杆菌的抗菌活性。这项工作表明了一种新方法，导致基于多酚的软材料而不是复杂的凝聚微观结构。所得的Ta-PEG水凝胶具有生物医学材料的潜在应用。

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  • 来源
    《RSC Advances》 |2020年第3期|共9页
  • 作者

    Chen Chen; Geng Xi-wen; Pan Ya-hui; Ma Yu-ning; Ma Yu-xia; Gao Shu-zhong; Huang Xiao-jun;

  • 作者单位

    Shandong Univ Tradit Chinese Med Dept Acupuncture Moxibust &

    Tuina New Mat Res Inst Key Lab Jinan 250355 Peoples R China;

    Shandong Univ Tradit Chinese Med Expt Ctr Key Lab Stem Cell &

    Translat TCM Jinan 250355 Peoples R China;

    Shandong Univ Tradit Chinese Med Dept Acupuncture Moxibust &

    Tuina New Mat Res Inst Key Lab Jinan 250355 Peoples R China;

    Shandong Univ Tradit Chinese Med Dept Acupuncture Moxibust &

    Tuina New Mat Res Inst Key Lab Jinan 250355 Peoples R China;

    Shandong Univ Tradit Chinese Med Dept Acupuncture Moxibust &

    Tuina New Mat Res Inst Key Lab Jinan 250355 Peoples R China;

    Shandong Univ Tradit Chinese Med Dept Acupuncture Moxibust &

    Tuina New Mat Res Inst Key Lab Jinan 250355 Peoples R China;

    Zhejiang Univ Dept Polymer Sci &

    Engn MOE Key Lab Macromol Synth &

    Functionalizat Hangzhou 310027 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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