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Exploiting the native inspiratory ability of a mass spectrometer to improve analysis efficiency

机译：利用质谱仪的本机吸气能力，提高分析效率

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摘要

In this study, a new approach to perform self-aspirating sampling in mass spectrometry (MS) analysis was developed by using the native inspiratory ability of a mass spectrometer. Specifically, the inspiratory channel and sampling inlet of the MS instrument were integrated into a single pathway through a sealed ionization chamber to facilitate analyte delivery and improve sample utilization. Based on this approach, combined with structural simplification and optimization, a versatile electrospray ionization (ESI) source has been constructed and characterized using different mass spectrometers. In addition to the self-aspirating ability, this source configuration can provide sub-ambient pressure (SAP) conditions for ionization, which were conducive to suppressing the background ions generated from some air-involved reactions. Moreover, it can also be used directly for electrospray-driven extraction ionization. With the SAP-ESI source, a conventional mass spectrometer enables rapid analysis of both volatiles and solutions via secondary electrospray ionization and coaxial electrospray ionization, respectively. As the compact gas pathway of the source will promote the efficient transfer and ionization of the sampled substances, the total consumption of the analyte for each analysis can be reduced to subnanogram level and a subppbv limit detection is achieved. Other demonstrated features such as the versatility, easy operation as well as simple assembly will likely contribute to the prevalence of the proposed sampling and ionization strategy.
机译：在该研究中，通过使用质谱仪的天然吸气能力开发了一种新的在质谱中进行自吸式取样的新方法。具体地，MS仪器的吸气通道和取样入口通过密封的电离室整合到单个途径中，以促进分析物递送并改善样品利用率。基于这种方法，结合结构简化和优化，使用不同的质谱仪构建和表征了多功能电喷雾电离（ESI）源。除了自吸能能力之外，该源配置还可以提供用于电离的亚环境压力（SAP）条件，其有利于抑制来自一些呼吸反应产生的背景离子。此外，它也可以直接用于电喷雾驱动的提取电离。通过SAP-ESI源，传统的质谱仪可以通过分别通过二次电喷雾电离和同轴电喷雾电离快速分析挥发物和溶液。随着源的紧凑气体途径将促进采样物质的有效转移和电离，每个分析的分析物的总消耗可以降低到亚网图水平，并且实现了子PPV限制检测。其他展示的特征，如多功能性，操作简便以及简单的组装可能有助于提出的采样和电离策略的普及。

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  • 来源
    《RSC Advances》 |2020年第7期|共7页
  • 作者

    Zhang Qian; Lin Lin; Yu Quan; Wang Xiaohao;

  • 作者单位

    Tsinghua Shenzhen Int Grad Sch Div Adv Mfg Shenzhen 518055 Peoples R China;

    Southern Univ Sci &

    Technol Mat Characterizat &

    Preparat Ctr Shenzhen 518055 Peoples R China;

    Tsinghua Shenzhen Int Grad Sch Div Adv Mfg Shenzhen 518055 Peoples R China;

    Tsinghua Shenzhen Int Grad Sch Div Adv Mfg Shenzhen 518055 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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