Isolation and characterization of novel acetylcholinesterase inhibitors fromFicus benghalensisL. leaves

Hassan Heba Ali; Allam Ahmed E.; Abu-Baih Dalia H.; Mohamed Mamdouh F. A.; Abdelmohsen Usama Ramadan; Shimizu Kuniyoshi; Desoukey Samar Y.; Hayallah Alaa M.; Elrehany Mahmoud A.; Mohamed Khaled M.; Kamel Mohamed S.

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Isolation and characterization of novel acetylcholinesterase inhibitors fromFicus benghalensisL. leaves

机译：新型乙酰胆碱酯酶抑制剂的分离与表征Fromus Benghalensisl。树叶

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Metabolic profiling of the crude methanolic extract ofFicus benghalensisleaves has revealed the presence of different phenolic and nitrogenous compounds including cerebrosides and tetrapyrrole pigments. A phytochemical study of the ethyl acetate fraction resulted in the identification of three known compounds, namely carpachromene (1), alpha amyrine acetate (2), and mucusoside (3) together with one new fatty acid glycoside, named 2-O-alpha-l-rhamnopyranosyl-hexacosanoate-beta-d-glucopyranosyl ester (4). The compounds were identified using 1D, 2D NMR, and HR-ESIMS techniques as well asviacomparison to other literature. Studies on the acetylcholinesterase inhibition potential and antioxidant activity were carried out on the total methanolic leaf extract, ethyl acetate fraction, and the isolated compounds. The results revealed the potent acetylcholinesterase inhibition of mucusoside alongside a new compound. Docking studies were also performed to confirm the possible interaction between the isolated compounds and acetylcholinesterase accompanying Alzheimer's disease progress.

机译：粗甲醇提取物Officus Benghalensissleaves的代谢谱揭示了不同酚类和氮化合物的存在，包括大脑和四吡咯颜料。乙酸乙酯级分的植物化学研究导致鉴定三种已知的化合物，即肉甲甲丙烯烯（1），α芳丙烯酸乙酸乙酸酯（2）和粘液苷（3），与一种新的脂肪酸糖苷一起命名为2-O-α- L- rham吡喃糖基 - 六烷醇酸β-D-吡喃葡萄糖酯（4）。使用1D，2D NMR和HR-ESIMS技术鉴定化合物，以及其他文献的AsviaComparison。对乙酰胆碱酯酶抑制电位和抗氧化活性的研究在总甲醇叶片提取物，乙酸乙酯馏分和分离的化合物上进行。结果揭示了新化合物旁边粘液皂苷的有效乙酰胆碱酯酶抑制。还进行了对接研究以确认分离的化合物和乙酰胆碱酯酶之间的可能相互作用伴随阿尔茨海默病进展。

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《RSC Advances》 |2020年第60期|共10页
作者
Hassan Heba Ali; Allam Ahmed E.; Abu-Baih Dalia H.; Mohamed Mamdouh F. A.; Abdelmohsen Usama Ramadan; Shimizu Kuniyoshi; Desoukey Samar Y.; Hayallah Alaa M.; Elrehany Mahmoud A.; Mohamed Khaled M.; Kamel Mohamed S.;
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Deraya Univ Fac Pharm Dept Pharmacognosy New Minia City 61111 Egypt;

Al Azhar Univ Fac Pharm Dept Pharmacognosy Assiut 71524 Egypt;

Deraya Univ Fac Pharm Dept Biochem &

Mol Biol New Minia City 61111 Egypt;

Sohag Univ Fac Pharm Dept Pharmaceut Chem Sohag 82524 Egypt;

Deraya Univ Fac Pharm Dept Pharmacognosy New Minia City 61111 Egypt;

Kyushu Univ Grad Sch Bioresource &

Bioenvironm Sci Dept Agroenvironm Sci Fukuoka 8190395 Japan;

Menia Univ Fac Pharm Dept Pharmacognosy Al Minya 61519 Egypt;

Deraya Univ Fac Pharm Dept Pharmaceut Chem New Minia City 61111 Egypt;

Deraya Univ Fac Pharm Dept Biochem &

Mol Biol New Minia City 61111 Egypt;

Fayoum Univ Fac Pharm Dept Pharmacognosy Al Fayyum 63514 Egypt;

Deraya Univ Fac Pharm Dept Pharmacognosy New Minia City 61111 Egypt;

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正文语种 eng
中图分类化学;
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1. Isolation and characterization of novel acetylcholinesterase inhibitors fromFicus benghalensisL. leaves [J] . Hassan Heba Ali, Allam Ahmed E., Abu-Baih Dalia H., RSC Advances . 2020,第60期

机译：新型乙酰胆碱酯酶抑制剂的分离与表征Fromus Benghalensisl。树叶
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7. Isolation and characterization of novel acetylcholinesterase inhibitors from Ficus benghalensis L. leaves [O] . Heba Ali Hassan, Ahmed E. Allam, Dalia H. Abu-Baih, 2020

机译：Ficus Benghalensis L.叶片新乙酰胆碱酯酶抑制剂的分离与表征

Isolation and characterization of novel acetylcholinesterase inhibitors fromFicus benghalensisL. leaves

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