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A tumor-microenvironment-responsive nanomaterial for cancer chemo-photothermal therapy

机译：一种肿瘤微环境反应纳米材料，用于癌症化疗 - 光热疗法

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摘要

Taxol (TAX) is a typical anticancer drug that is widely used in clinical treatment of cancer, while gold nanorods (AuNRs) are a kind of well-known material applied for photothermal therapy (PTT). The therapeutic outcome of TAX in chemotherapy is however limited by drug resistance, while AuNRs often show poor accuracy in PTT. To optimize the functions of TAX and AuNRs, we developed a hydrogen peroxide (H2O2)-triggered nanomaterial (LV-TAX/Au@Ag) for combined chemo-photothermal therapy. In normal tissues, TAX is protected in the lipid bilayer and isolated from the surrounding normal cells, while AuNRs are coated with silver shells and show low photothermal capacity. However, after reaching the tumor tissues, the silver shells can be etched by endogenous H(2)O(2)in the tumor microenvironment, and the photothermal properties of AuNRs are then recovered. Meanwhile, the generated oxygen destabilizes the LV, which makes the 100 nm sized nanosystems disassemble into the smaller sized TAX and AuNRs, leading to the deep penetration and direct interaction with tumor tissues. The relatedin vitroexperiments proved the validity of this "turn off/on" effect. Extensive necrosis and apoptosis were observed in the tumor tissues and the proliferation of solid tumor was greatly suppressed due to this combined chemo-photothermal therapy. In addition, no significant damage was found in normal tissues after the treatment of LV-TAX/Au@Ag. Therefore, the strategy to achieve environmental response by modifying the photothermal agents enhanced the efficiency and safety of nanomedicine, which may help improve cancer treatment.
机译：紫杉醇（税）是一种典型的抗癌药，广泛应用于癌症的临床治疗，而金纳米棒（AUNRS）是一种施加用于光热疗法（PTT）的知名材料。然而，化疗税的治疗结果受到耐药性的限制，而AUNR在PTT中经常表现出差的准确性。为了优化税和AUNR的功能，我们开发了一种用于组合化疗 - 光热疗法的过氧化氢（H2O2） - 载有纳米材料（LV-税/ AU @ AG）。在正常组织中，税收在脂质双层中保护并与周围的正常细胞分离，而AUNRS涂有银壳并显示出低光热容量。然而，在到达肿瘤组织之后，可以通过肿瘤微环境中的内源H（2）O（2）蚀刻银壳，然后回收AUNR的光热性质。同时，所产生的氧气使LV失去稳定，这使得100nm大小的纳米系统拆卸成较小的税和AUNR，导致肿瘤组织的深度渗透和直接相互作用。相关的vitrooxperiments证明了这种“关掉/上”效果的有效性。在肿瘤组织中观察到广泛的坏死和细胞凋亡，由于该组合的化学光热疗法，大大抑制了固体瘤的增殖。此外，在治疗LV税/ AU @ AG后，正常组织中没有发现显着损害。因此，通过改变光热试剂来实现环境响应的策略增强了纳米医生的效率和安全性，这可能有助于改善癌症治疗。

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  • 来源
    《RSC Advances》 |2020年第37期|共11页
  • 作者

    Wang Kaiyu; Cai Zhiyuan; Fan Rong; Yang Qian; Zhu Tao; Jiang Zhongying; Ma Yuqiang;

  • 作者单位

    Nanjing Univ Collaborat Innovat Ctr Adv Microstruct Dept Phys Natl Lab Solid State Microstruct Nanjing Peoples R China;

    Nanjing Univ Collaborat Innovat Ctr Adv Microstruct Dept Phys Natl Lab Solid State Microstruct Nanjing Peoples R China;

    Yili Normal Univ Key Lab Micronano Elect Sensing Technol &

    Bion De Coll Elect &

    Informat Engn Yining Peoples R China;

    Yili Normal Univ Key Lab Micronano Elect Sensing Technol &

    Bion De Coll Elect &

    Informat Engn Yining Peoples R China;

    Nanjing Univ Collaborat Innovat Ctr Adv Microstruct Dept Phys Natl Lab Solid State Microstruct Nanjing Peoples R China;

    Yili Normal Univ Key Lab Micronano Elect Sensing Technol &

    Bion De Coll Elect &

    Informat Engn Yining Peoples R China;

    Nanjing Univ Collaborat Innovat Ctr Adv Microstruct Dept Phys Natl Lab Solid State Microstruct Nanjing Peoples R China;

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  • 中图分类 化学;
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