CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review

Rani Alisha; Singh Gurjaspreet; Singh Akshpreet; Maqbool Ubair; Kaur Gurpreet; Singh Jandeep

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CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review

机译：Cuaac-enclembled的1,2,3-三唑连接的旁观者作为药物发现的药物：审查

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The review lays emphasis on the significance of 1,2,3-triazoles synthesized via CuAAC reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory, anti-tuberculosis, anti-diabetic, and anti-Alzheimer drugs. The importance of click chemistry is due to its 'quicker' methodology that has the capability to create complex and efficient drugs with high yield and purity from simple and cheap starting materials. The activity of different triazolyl compounds was compiled considering MIC, IC50, and EC50 values against different species of microbes. In addition to this, the anti-oxidant property of triazolyl compounds have also been reviewed and discussed.

机译：审查强调通过Cuaac反应合成的1,2,3-三唑的意义，其具有抗微生物，抗癌，抗病毒，抗炎，抗结核，抗糖尿病和抗糖尿病和反 -Alzheimer药物。点击化学的重要性是由于其“更快”的方法，具有能力创造具有高产和纯度的复杂和高效的药物，从简单和廉价的起始材料。考虑MIC，IC50和EC50对不同种类的微生物的EC50值编制不同三唑基化合物的活性。除此之外，还讨论并讨论了三唑基化合物的抗氧化性能。

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来源
《RSC Advances》 |2020年第10期|共26页
作者
Rani Alisha; Singh Gurjaspreet; Singh Akshpreet; Maqbool Ubair; Kaur Gurpreet; Singh Jandeep;
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作者单位

Lovely Profess Univ Dept Chem Phagwara 144411 Punjab India;

Panjab Univ Ctr Adv Studies Chem Dept Chem Chandigarh 160014 India;

Panjab Univ Ctr Adv Studies Chem Dept Chem Chandigarh 160014 India;

Lovely Profess Univ Dept Chem Phagwara 144411 Punjab India;

Gujranwala Guru Nanak Khalsa Coll Dept Chem Ludhiana 141001 Punjab India;

Lovely Profess Univ Dept Chem Phagwara 144411 Punjab India;

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正文语种 eng
中图分类化学;
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1. CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review [J] . Rani Alisha, Singh Gurjaspreet, Singh Akshpreet, RSC Advances . 2020,第10期

机译：Cuaac-enclembled的1,2,3-三唑连接的旁观者作为药物发现的药物：审查
2. Triazole-linked reduced amide isosteres: an approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors. [J] . Monceaux CJ, Hirata Fukae C, Lam PC, Bioorganic and Medicinal Chemistry Letters . 2011,第13期

机译：三唑连接的还原酰胺等位基因：一种基于片段的抗阿尔茨海默氏病BACE1抑制剂药物发现方法。
3. Triazole-linked reduced amide isosteres: an approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors. [J] . Monceaux CJ, Hirata Fukae C, Lam PC, Bioorganic and Medicinal Chemistry Letters . 2011,第13期

机译：三唑连接的还原酰胺等位基因：一种基于片段的抗阿尔茨海默氏病BACE1抑制剂药物发现方法。
4. Synthesis and characterization of 1-amino-4-nitro-1,2,3-triazole and 2-amino-4-nitro-1,2,3-triazole [C] . Dominique R. Wozniak, Benjamin Salfer, Matthias Zeller, . 2020

机译：1-氨基-4-硝基-1,2,3-三唑和2-氨基-4-硝基-1,2,3-三唑的合成与表征
5. Achieving bright blue phosphorescent platinum(II) compounds with cyclometallating phenyl-1,2,3-triazole ligands. [D] . Wang, Xiang. 2017

机译：实现具有环金属化苯基-1,2,3-三唑配体的亮蓝色磷光铂（II）化合物。
6. Modular Approach to Triazole-Linked 16-α-D-Oligomannosides to the Discovery of Inhibitors of Mycobacterium tuberculosis Cell Wall Synthetase [O] . Mauro Lo Conte, Alberto Marra, Angela Chambery, -1

机译：模块化的方法来三唑连接的16-α-d-Oligomannosides到结核分枝杆菌细胞壁合成酶的抑制剂的发现
7. CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review [O] . Alisha Rani, Gurjaspreet Singh, Akshpreet Singh, 2020

机译：Cuaac-enclembled的1,2,3-三唑连接的旁观者作为药物发现的药物：审查
8. Synthesis, Characterization, and Structural Investigations of 1-amino-3-Substituted- 1,2,3-Triazolium Salts, and a New Route to 1-substituted-1,2,3- triazoles [R] . Kaplan, G. , Drake, G. , Tollison, K. , 2004

机译：1-氨基-3-取代-1,2,3-三唑盐的合成，表征和结构研究，以及1-取代-1,2,3-三唑的新途径

CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review

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