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The potential of Thymus vulgaris aqueous extract to protect against delayed gastric emptying and colonic constipation in rats

机译：紫紫豆含水提取物的潜力，以防止大鼠延迟胃排空和结肠便秘

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摘要

Thyme is a rich source of bioactive phytochemicals and it is frequently used in folk-medicine to treat gastroenteritis irritations. The current study was performed to examine the potential of Thymus vulgaris aqueous extract (TV-AE) to protect against delayed gastric emptying (DGE) and colonic constipation in rats. Stomach ulcer was caused by a single oral dose administration of indomethacin (INDO) (30 mg kg(-1) of body weight). Constipation was induced following intravenous intoxication of rats with vinblastine (VINB) (2 mg kg(-1) of body weight) for one week. The effect of TV-AE at two graduated doses (100 and 200 mg kg(-1)) on DGE, gastrointestinal transit (GIT) and constipated rats and biochemical parameters was estimated using phenol red, charcoal meal test and colorimetric methods, respectively. The phytochemical-profile of TV-AE was explored using high-performance liquid chromatography coupled with photodiode array detection and electrospray ionization-mass spectrometry (HPLC-PDA/ESI-MS). INDO and VINB caused a significant reduction in (P < 0.05) DGE and GIT and colonic motility dysfunction. TV-AE consumption remarkably (P < 0.05) attenuated the DGE (from 58.56% to 69.871%) and difficulty in evacuating stools (from 48.5 to 55.5 fecal pellets per rat) and balanced the GIT (65% to 71%). These GI-ameliorative effects were accompanied by reversed INDO/VINB-related oxidative changes, lipid-metabolism alteration and intracellular pathway moderation. HPLC-PDA/ESI-MS-analysis identified several chemical constituents including rosmarinic acid, quinic acid, luteolin-7-o-glucoside, protocatechuic acid and trans-cinnamic acid. Thus, TV-AE bioactive components may be used as medicinal substances to regulate/attenuate gastrointestinal-physiological activities and disturbances, which support its pharmacological use.
机译：百里香是一种丰富的生物活性植物化学来源，它经常用于民间医学以治疗胃肠炎刺激。进行目前的研究以检查胸腺紫色含水提取物（TV-AE）的潜力，以防止延迟胃排空（DGE）和大鼠结肠便秘。胃溃疡是由吲哚美辛（Indo）（Indo）（30mg kg（-1）体重）引起的。在静脉注射大鼠静脉注射大鼠（VINB）（2mg kg（-1）体重）诱导一周的诱导便秘。使用酚红，木炭膳食测试和比色方法估计了在DGE，胃肠道转发（GIT）和便秘的大鼠和生物化学参数上的两个渐变剂量（100和200mg kg（-1））的影响。使用高性能液相色谱法耦合与光电二极管阵列检测和电喷雾电离质谱（HPLC-PDA / ESI-MS）的高效液相色谱法探索了TV-AE的植物化学型材。印度和VINB导致（P <0.05）DGE和Git和结肠运动功能障碍的显着减少。电视 - AE消耗显着（P <0.05）衰减了DGE（从58.56％至69.871％），难以抽出粪便（每只大鼠的48.5至55.5次粪便颗粒）并平衡Git（65％至71％）。这些GI-改善效果伴随着逆转的印度/ vinB相关的氧化变化，脂质代谢改变和细胞内途径适度。 HPLC-PDA / ESI-MS-分析确定了几种化学成分，包括甘氨酸，醋酸，叶氏菌素-7-O-葡糖苷，ProtocateChuic酸和反式肉桂酸。因此，TV-AE生物活性成分可用作药物物质以调节/衰减胃肠生理活性和扰动，其支持其药理学用途。

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  • 来源
    《RSC Advances》 |2019年第36期|共10页
  • 作者

    Rtibi Kais; Selmi Slimen; Wannes Dalanda; Jridi Mourad; Marzouki Lamjed; Sebai Hichem;

  • 作者单位

    Univ Jendouba Higher Inst Biotechnol Beja Lab Funct Physiol &

    Valorizat Bioresources BP 382 Beja 9000 Tunisia;

    Univ Jendouba Higher Inst Biotechnol Beja Lab Funct Physiol &

    Valorizat Bioresources BP 382 Beja 9000 Tunisia;

    Univ Jendouba Higher Inst Biotechnol Beja Lab Funct Physiol &

    Valorizat Bioresources BP 382 Beja 9000 Tunisia;

    Univ Sfax Natl Sch Engineers Sfax Lab Enzymat Engn &

    Microbiol BP 1173 Sfax 3038 Tunisia;

    Univ Jendouba Higher Inst Biotechnol Beja Lab Funct Physiol &

    Valorizat Bioresources BP 382 Beja 9000 Tunisia;

    Univ Jendouba Higher Inst Biotechnol Beja Lab Funct Physiol &

    Valorizat Bioresources BP 382 Beja 9000 Tunisia;

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  • 正文语种 eng
  • 中图分类 化学;
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