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Cisplatin delivery, anticancer and antibacterial properties of Fe/SBA-16/ZIF-8 nanocomposite

机译：Cisplatin递送，抗癌和Fe / Sba-16 / ZIF-8纳米复合材料的抗菌性能

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Nanoformulation involving biocompatible MOFs and magnetic nanocarriers is an emerging multifunctional platform for drug delivery and tumor imaging in targeted cancer therapeutics. In this study, a nanocomposite has been developed comprising Fe/SBA-16 and ZIF-8 (Fe/S-16/ZIF-8) through ultrasonication. The drug delivery of cisplatin was studied using an automated diffusion cell system equipped with a flow type Franz cell. The anticancer activity of Fe/S-16/ZIF-8 was studied in vitro in MCF-7, HeLa cells and Human Foreskin Fibroblast (HFF-1) cells. XRD and d-spacing measurements of Fe/S-16/ZIF-8 using TEM revealed the presence of cubic-structured Fe3O4, gamma-Fe2O4 (magnetite), and alpha-FeOOH (goethite) over an SBA-16/ZIF-8 nanocomposite. The composite showed a surface area of 365 m(2) g(-1), a pore size of 8.3 nm and a pore volume of 0.33 cm(3) g(-1). VSM analysis of Fe/S-16/ZIF-8 showed that it possessed paramagnetic behavior with a saturated magnetization value of 2.39 emu g(-1). The Fe2+/Fe3+ coordination environment was characterized using diffuse reflectance spectroscopy. The cisplatin drug delivery study clearly showed the synergistic effects present in Fe/S-16/ZIF-8 with over 75% of cisplatin release as compared to that of Fe/S-16 and ZIF-8, which showed 56% and 7.5%, respectively. The morphology analysis of CP/Fe/SBA-16/ZIF-8 using TEM showed an effective transit of nanoparticles into MCF-7 cells. The lethal concentration (LC50) of Fe/SBA-16/ZIF-8 for MCF-7 and HeLa cells is 0.119 mg mL(-1) and 0.028 mg mL(-1) at 24 h, respectively. For HFF-1 cells, the LC50 is 0.016 mg mL(-1). The antibiofilm activity of Fe/SBA-16/ZIF-8 was investigated against biofilm-forming strains of drug resistant P. aeruginosa and MRSA by a microtiter tissue culture plate assay. Overall, nanosized ZIF-8 with a bioactive alkaloid imidazole inside the 3D cage type of SBA-16 pores is found to exhibit both anticancer and antibacterial properties. A Fe/S-16/ZIF-8 composite could be effectively used as a drug and drug delivery system against cancer and promote antibacterial activity.
机译：涉及生物相容性MOF和磁性纳米载体的纳米型测量是用于靶向癌症治疗剂中的药物递送和肿瘤成像的新出现的多功能平台。在该研究中，通过超声波含有Fe / Sba-16和Zif-8（Fe / S-16 / Zif-8），开发了一种纳米复合材料。使用配备有流动型Franz池的自动扩散电池系统顺铂的药物递送进行了研究。在MCF-7，Hela细胞和人包皮成纤维细胞（HFF-1）细胞中，在体外研究了Fe / S-16 / ZIF-8的抗癌活性。 Fe / S-16 / ZIF-8的XRD和D-间距测量使用TEM显示在SBA-16 / ZIF-8上的立方结构Fe3O4，Gamma-Fe2O4（磁铁矿）和α-FeO​​h（甲酸盐）的存在纳米复合材料。复合材料显示出365m（2 )g（-1）的表面积，孔径为8.3nm，孔体积为0.33cm（3）g（-1）。 Fe / S-16 / ZIF-8的VSM分析表明它具有饱和磁化值2.39 emu g（-1）的顺磁性行为。使用漫反射光谱表征Fe2 + / Fe3 +配位环境。顺铂药物递送研究表明，与Fe / S-16和ZIF-8相比，Fe / S-16 / ZIF-8中存在的协同效应具有超过75％的顺铂释放，其显示为56％和7.5％ ， 分别。 CP / Fe / SBA-16 / ZIF-8使用TEM的形态分析显示有效的纳米颗粒进入MCF-7细胞。用于MCF-7和HeLa细胞的Fe / SBA-16 / ZIF-8的致死浓度（LC50）分别为24小时的0.119mg ml（-1）和0.028mg（-1）。对于HFF -1细胞，LC50为0.016mg ml（-1）。通过微量滴定组织培养板测定研究了Fe / SBA-16 / ZIF-8的抗毒性毒性P.铜绿假单胞菌和MRSA的生物膜形成菌株。总体而言，发现纳米ZIF-8与3D笼式的3D笼式的SBA-16孔隙中的生物活性生物碱咪唑型表现出抗癌和抗菌性。可以有效地使用Fe / S-16 / ZIF-8复合材料作为针对癌症的药物和药物递送系统，促进抗菌活性。

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    《RSC Advances》 |2019年第72期|共14页
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