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首页> 外文期刊>RSC Advances >Construction of a graphene/polypyrrole composite electrode as an electrochemically controlled release system
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Construction of a graphene/polypyrrole composite electrode as an electrochemically controlled release system

机译：将石墨烯/聚吡咯复合电极的构建为电化学控制的释放系统

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摘要

A new class of stimuli responsive drug delivery systems is emerging to establish new paradigms for enhancing therapeutic efficacy. To date, most electro-responsive systems rely on noble metal electrodes that likely cause the limitations for implantation applications. Herein, a graphene/polypyrrole composite electrode (GN-PPy-FL) was fabricated based on two-dimensional (2D) graphene (GN) film and conductive and biocompatible polypyrrole (PPy) nanoparticles loaded with a negative drug model of fluorescein sodium (FL) via chemical oxidation polymerization. The conductive composite electrode was utilized as a drug carrier to realize the electrically controlled release of the FL. The release rate from conductive nanoparticles can be controlled by the applied voltages. The study provides a multi-stimuli responsive drug release system, demonstrating the potential applications of the controlled release of various drugs, peptides or proteins.
机译：新一类刺激响应药物递送系统正在努力建立新的范式，以提高治疗效果。 迄今为止，大多数电响应系统依赖于贵金属电极，这可能导致植入应用的限制。 在此，基于二维（2D）石墨烯（GN）膜和导电和生物相容性的和生物相容的萘粒子（PPY）纳米粒子制备了石墨烯/聚吡咯复合电极（GN-PPY-FL），其中荧光素钠的负药物模型（FL） ）通过化学氧化聚合。 导电复合电极用作药物载体以实现F1的电控释放。 来自导电纳米颗粒的释放速率可以通过施加的电压来控制。 该研究提供了一种多刺激响应药物释放系统，展示了各种药物，肽或蛋白质的控释的潜在应用。

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  • 来源
    《RSC Advances》 |2019年第22期|共8页
  • 作者

    Zhu Mo; Hao Ying; Ma Xun; Feng Lin; Zhai Yuanxin; Ding Yaping; Cheng Guosheng;

  • 作者单位

    Shanghai Univ Dept Chem Shanghai 200444 Peoples R China;

    Chinese Acad Sci Suzhou Inst Nanotech &

    Nanobion CAS Key Lab Nanobio Interface Suzhou 215123 Jiangsu Peoples R China;

    Chinese Acad Sci Suzhou Inst Nanotech &

    Nanobion CAS Key Lab Nanobio Interface Suzhou 215123 Jiangsu Peoples R China;

    Chinese Acad Sci Suzhou Inst Nanotech &

    Nanobion CAS Key Lab Nanobio Interface Suzhou 215123 Jiangsu Peoples R China;

    Chinese Acad Sci Suzhou Inst Nanotech &

    Nanobion CAS Key Lab Nanobio Interface Suzhou 215123 Jiangsu Peoples R China;

    Shanghai Univ Dept Chem Shanghai 200444 Peoples R China;

    Chinese Acad Sci Suzhou Inst Nanotech &

    Nanobion CAS Key Lab Nanobio Interface Suzhou 215123 Jiangsu Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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