UPLC-QTOF-MS-guided isolation of anti-COPD ginsenosides from wild ginseng

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UPLC-QTOF-MS-guided isolation of anti-COPD ginsenosides from wild ginseng

机译：UPLC-QTOF-MS-引导野生人参抗COPD人参皂苷的隔离

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Four previously undescribed ginsenosides, along with five known analogues were isolated from wild ginseng by a UPLC-QTOF-MS-guided fractionation procedure. Their structures were elucidated on the basis of spectroscopic and spectrometric data (1D and 2D NMR, HR-ESI-MS). The isolated compounds could significantly inhibit the cigarette smoke extract (CSE)-induced inflammatory reaction in A549 cells. The HDAC2 pathway might be involved in the protective effect against the CSE-mediated inflammatory response in A549 cells.

机译：通过UPLC-QTOF-MS引导的分馏程序从野生人参中分离出四个以前未描述的人参皂苷。它们的结构基于光谱和光谱数据（1D和2D NMR，HR-ESI-MS）阐明。分离的化合物可显着抑制香烟烟雾提取物（CSE）诱导的A549细胞炎症反应。 HDAC2途径可能涉及对A549细胞中CSE介导的炎症反应的保护作用。

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《RSC Advances》 |2019年第66期|共11页
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正文语种 eng
中图分类化学;
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1. UPLC-QTOF-MS-guided isolation of anti-COPD ginsenosides from wild ginseng [J] . RSC Advances . 2019,第66期

机译：UPLC-QTOF-MS-引导野生人参抗COPD人参皂苷的隔离
2. Component analysis of cultivated ginseng, cultivated wild ginseng, and wild ginseng and the change of ginsenoside components in the process of red ginseng. [J] . Jeong HS, Lim CS, Cha BC, Journal of Pharmacopuncture . 2010,第1期

机译：栽培人参，栽培野山参和野山参的成分分析以及红参过程中人参皂甙成分的变化。
3. Effective Purification of Ginsenosides from Cultured Wild Ginseng Roots, Red Ginseng, and White Ginseng with Macroporous Resins [J] . Li Huayue, Jae-Hwa Lee, Jong-Myung Ha Journal of microbiology and biotechnology . 2008,第11期

机译：利用大孔树脂从野山参，红参和白参中有效纯化人参皂苷
4. Identification of ginsenosides Rc, Rb2, Rb3 and related malonyl-ginsenosides in panax ginseng extracts by using RRLC-Q-TOF-MS/MS [C] . Jinghui Sun, Jun Mi, Qiujie Qin, 2011 International Conference on Human Health and Biomedical Engineering . 2011

机译：用RRLC-Q-TOF-MS / MS鉴定人参提取物中的人参皂苷Rc，Rb 2 ，Rb 3 及相关的丙二酰人参皂苷
5. The effect of Korean red ginseng (Panax ginseng C.A. Mayer) on vascular function and influence of derived ginsenosides and polysaccharides. [D] . Jovanovski, Elena. 2007

机译：高丽红参（Panax ginseng C.A. Mayer）对血管功能的影响以及衍生的人参皂甙和多糖的影响。
6. Ginsenoside Production and Morphological Characterization of Wild Ginseng (Panax ginseng Meyer) Mutant Lines Induced by γ-irradiation (60Co) of Adventitious Roots [O] . Jun-Ying Zhang, Tae-Woong Bae, Kyung-Hwan Boo, 2011

机译：不定根γ射线（60Co）诱导的野生人参突变体品系的人参皂苷生成及形态特征
7. UPLC-QTOF-MS-guided isolation of anti-COPD ginsenosides from wild ginseng [O] . Hailin Zhu, Junli Liu, Hongqiang Lin, 2019

机译：UPLC-QTOF-MS-引导野生人参抗COPD人参皂苷的隔离

UPLC-QTOF-MS-guided isolation of anti-COPD ginsenosides from wild ginseng

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