Protecting group-directed annulations of tetra-substituted oxindole olefins and sulfur ylides: regio- and chemoselective synthesis of cyclopropane- and dihydrofuran-fused spirooxindoles

Kang Jing-Wen; Li Xiang; Chen Fei-Yu; Luo Yuan; Zhang Shu-Cang; Kang Bin; Peng Cheng; Tian Xu; Han Bo

首页> 外文期刊>RSC Advances >Protecting group-directed annulations of tetra-substituted oxindole olefins and sulfur ylides: regio- and chemoselective synthesis of cyclopropane- and dihydrofuran-fused spirooxindoles

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Protecting group-directed annulations of tetra-substituted oxindole olefins and sulfur ylides: regio- and chemoselective synthesis of cyclopropane- and dihydrofuran-fused spirooxindoles

机译：保护甲蛋白氧吲哚烯烃和硫含量的基团定向分布：依赖环丙烷和二氢呋喃熔融苯肟吲哚醛皂苷和化学选择合成

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Protecting group-controlled annulations of tetra-substituted oxindole olefins and sulfur ylides have been achieved for the synthesis of multifunctional cyclopropane- and dihydrofuran-fused spirooxindoles. Under precise annulation regulation, a variety of cyclopropane- and dihydrofuran-fused spirooxindoles containing vicinal quaternary carbon centers were produced in up to 90% yield with up to 20:1 dr. This reaction demonstrates high regio-, chemo- and diastereoselectivity, broad functional group tolerance and gram-scale capacity.

机译：已经达到了用于合成多官能环丙烷和二氢呋喃熔融苯肟吲哚的基于取代的氧吲哚烯烃和硫酰胺的基于取代的氧吲哚烯烃和硫酰胺的基团控制。在精确的环状调节下，含有静脉季碳中心的各种环丙烷和二氢呋喃熔螺氧吲哚吲哚吲哚吲哚，高达90％的产率，高达20：1博士。该反应显示出高的Regio - ，化学和非对映选择性，宽的官能团耐受性和革兰垢容量。

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来源
《RSC Advances》 |2019年第22期|共10页
作者
Kang Jing-Wen; Li Xiang; Chen Fei-Yu; Luo Yuan; Zhang Shu-Cang; Kang Bin; Peng Cheng; Tian Xu; Han Bo;
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作者单位

Chengdu Univ Tradit Chinese Med Sch Pharm State Key Lab Breeding Base Systemat Res Dev &

Ut Chengdu 611137 Sichuan Peoples R China;

Chengdu Univ Tradit Chinese Med Sch Pharm State Key Lab Breeding Base Systemat Res Dev &

Ut Chengdu 611137 Sichuan Peoples R China;

Chengdu Univ Tradit Chinese Med Sch Pharm State Key Lab Breeding Base Systemat Res Dev &

Ut Chengdu 611137 Sichuan Peoples R China;

Chengdu Univ Tradit Chinese Med Sch Pharm State Key Lab Breeding Base Systemat Res Dev &

Ut Chengdu 611137 Sichuan Peoples R China;

Chengdu Univ Tradit Chinese Med Sch Pharm State Key Lab Breeding Base Systemat Res Dev &

Ut Chengdu 611137 Sichuan Peoples R China;

Chengdu Univ Tradit Chinese Med Sch Pharm State Key Lab Breeding Base Systemat Res Dev &

Ut Chengdu 611137 Sichuan Peoples R China;

Chengdu Univ Tradit Chinese Med Sch Pharm State Key Lab Breeding Base Systemat Res Dev &

Ut Chengdu 611137 Sichuan Peoples R China;

Guangzhou Med Univ Key Lab Mol Target &

Clin Pharmacol Guangzhou 511436 Guangdong Peoples R China;

Chengdu Univ Tradit Chinese Med Sch Pharm State Key Lab Breeding Base Systemat Res Dev &

Ut Chengdu 611137 Sichuan Peoples R China;

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正文语种 eng
中图分类化学;
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1. Protecting group-directed annulations of tetra-substituted oxindole olefins and sulfur ylides: regio- and chemoselective synthesis of cyclopropane- and dihydrofuran-fused spirooxindoles [J] . Kang Jing-Wen, Li Xiang, Chen Fei-Yu, RSC Advances . 2019,第22期

机译：保护甲蛋白氧吲哚烯烃和硫含量的基团定向分布：依赖环丙烷和二氢呋喃熔融苯肟吲哚醛皂苷和化学选择合成
2. Protecting group-directed annulations of tetra-substituted oxindole olefins and sulfur ylides: regio- and chemoselective synthesis of cyclopropane- and dihydrofuran-fused spirooxindoles [J] . Jing-Wen Kang, Xiang Li, Fei-Yu Chen, RSC Advances . 2019,第22期

机译：四取代的羟吲哚烯烃和硫醚的保护基导向的环空：环丙烷和二氢呋喃稠合的spirooxindoles的区域和化学选择性合成
3. Protecting group-directed annulations of tetra-substituted oxindole olefins and sulfur ylides: regio- and chemoselective synthesis of cyclopropane- and dihydrofuran-fused spirooxindoles [J] . Jing-Wen Kang, Xiang Li, Fei-Yu Chen, RSC Advances . 2019,第22期

机译：四取代的羟吲哚烯烃和硫醚的保护基导向的环空：环丙烷和二氢呋喃稠合的spirooxindoles的区域和化学选择性合成
4. Regio- and stereoselective synthesis of spiropyrrolidine-oxindole and bis-spiropyrrolizidine-oxindole grafted macrocycles through 3 + 2 cycloaddition of azomethine ylides [O] . Perumal Prabhakaran, Perumal Rajakumar 2020

机译：螺吡咯烷 - 氧吲哚和双螺吡咯烷酰胺 - 氧吲哚通过3 + 2环加成氮杂甲酰胺的植物和立体环形合成

Protecting group-directed annulations of tetra-substituted oxindole olefins and sulfur ylides: regio- and chemoselective synthesis of cyclopropane- and dihydrofuran-fused spirooxindoles

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