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首页> 外文期刊>RSC Advances >Investigation of the adsorption behavior of BSA with tethered lipid layer-modified solid-state nanopores in a wide pH range
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Investigation of the adsorption behavior of BSA with tethered lipid layer-modified solid-state nanopores in a wide pH range

机译：在宽pH范围内具有束缚脂层改性固态纳米孔的BSA吸附行为的研究

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摘要

Nanopore technology was introduced for the study of the dynamic interactions between bovine serum albumin (BSA) and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) phospholipids based on a modified nanopore. The results reveal that the interaction mechanism between DOPE and BSA is affected by the pH of the subphase. Far above the BSA isoelectric point (pH > 7), a weaker hydrophobic interaction and stronger electrostatic repulsion exist between the DOPE and BSA molecules. At pH = 7, the BSA structure nearly does not change, and the interaction is weak. At pH 5 and pH 6, BSA is marginally affected by the adsorption interaction, and below pH 5, the DOPE film becomes disordered, so there is a strong repulsive force interaction between the BSA and DOPE.
机译：纳米孔技术介绍了基于改性纳米孔的牛血清白蛋白（BSA）和1,2-二脲-Sn-甘油胺（掺杂）磷脂的动态相互作用研究。 结果表明，涂料和BSA之间的相互作用机制受到亚相的pH的影响。 远高于BSA等电点（pH> 7），在涂料和BSA分子之间存在较弱的疏水相互作用和较强的静电排斥。 在pH = 7时，BSA结构几乎不会改变，并且相互作用弱。 在pH5和pH 6中，BSA受吸附相互作用的略微影响，并且低于pH5，掺杂膜变得混乱，因此BSA和涂料之间存在强烈的排斥力相互作用。

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  • 来源
    《RSC Advances》 |2019年第27期|共6页
  • 作者

    Tian Haibing; Xie Wanyi; He Shixuan; Zhou Daming; Fang Shaoxi; Liang Liyuan; Wang Deqiang;

  • 作者单位

    Chinese Acad Sci Chongqing Inst Green &

    Intelligent Technol Chongqing 400714 Peoples R China;

    Chinese Acad Sci Chongqing Inst Green &

    Intelligent Technol Chongqing 400714 Peoples R China;

    Chinese Acad Sci Chongqing Inst Green &

    Intelligent Technol Chongqing 400714 Peoples R China;

    Chinese Acad Sci Chongqing Inst Green &

    Intelligent Technol Chongqing 400714 Peoples R China;

    Chinese Acad Sci Chongqing Inst Green &

    Intelligent Technol Chongqing 400714 Peoples R China;

    Chinese Acad Sci Chongqing Inst Green &

    Intelligent Technol Chongqing 400714 Peoples R China;

    Chinese Acad Sci Chongqing Inst Green &

    Intelligent Technol Chongqing 400714 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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