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首页> 外文期刊>RSC Advances >Conformational transition of a non-associative fluorinated amphiphile in aqueous solution. II. Conformational transition vs. supramolecular assembly
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Conformational transition of a non-associative fluorinated amphiphile in aqueous solution. II. Conformational transition vs. supramolecular assembly

机译：非关联氟化两亲层在水溶液中的构象过渡。 II。 构象过渡与超分子组件

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摘要

Unlike many known amphiphiles, the fluorinated amphiphilic dendrimer studied in this work demonstrated a concentration-dependent conformational transition rather than micellization or assembly. Hydrophobic and hydrophilic interactions with water were suggested as the most probable driving force of this transition. This assumption was consistent with the observed F-19 chemical shift changes of the dendrimer compared to a known micelle-forming fluorinated amphiphile. Since water is an important factor in the process, trends of the concentration-dependent changes in water proton transverse relaxation rate served as an indicator of structural changes and/or supramolecular assembly. The conformational transition process was also confirmed by ion-mobility mass-spectrometry. We suggested that structural features, namely, steric hindrances, prevented the micellization/assembly of the dendrimer of this study. This conclusion might inform the approach to develop novel unconventional amphiphiles.
机译：与许多已知的两双层不同，在该工作中研究的氟化两亲性树枝状器表现出浓度依赖性构象过渡而不是胶束化或组装。 建议与水的疏水性和亲水性相互作用作为该转变的最可能的驱动力。 与已知的胶束形成氟化两亲咪素相比，这种假设与树枝状聚合物的观察到的F-19化学变化变化一致。 由于水是过程中的重要因素，因此水质子横向松弛率的浓度依赖性变化的趋势用作结构变化和/或超分子组装的指标。 通过离子迁移率质谱法证实了构象过渡过程。 我们建议结构特征，即空间障碍，阻止了本研究的树突式胶束化/组装。 这一结论可能会通知这种方法，培养新颖的非传统两亲的两栖动物。

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  • 来源
    《RSC Advances》 |2019年第4期|共11页
  • 作者

    Taraban Marc B.; Deredge Daniel J.; Smith Margaret E.; Briggs Katharine T.; Feng Yue; Li Yu; Jiang Zhong-Xing; Wintrode Patrick L.; Yu Yihua Bruce;

  • 作者单位

    Univ Maryland Dept Pharmaceut Sci Sch Pharm 20 Penn St Baltimore MD 21201 USA;

    Univ Maryland Dept Pharmaceut Sci Sch Pharm 20 Penn St Baltimore MD 21201 USA;

    Univ Maryland Dept Pharmaceut Sci Sch Pharm 20 Penn St Baltimore MD 21201 USA;

    Univ Maryland Dept Pharmaceut Sci Sch Pharm 20 Penn St Baltimore MD 21201 USA;

    Univ Maryland Dept Pharmaceut Sci Sch Pharm 20 Penn St Baltimore MD 21201 USA;

    Wuhan Univ Sch Pharmaceut Sci Wuhan 430071 Hubei Peoples R China;

    Wuhan Univ Sch Pharmaceut Sci Wuhan 430071 Hubei Peoples R China;

    Univ Maryland Dept Pharmaceut Sci Sch Pharm 20 Penn St Baltimore MD 21201 USA;

    Univ Maryland Dept Pharmaceut Sci Sch Pharm 20 Penn St Baltimore MD 21201 USA;

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  • 正文语种 eng
  • 中图分类 化学;
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  • 入库时间 2022-08-19 17:45:40

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