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首页> 外文期刊>RSC Advances >Fabrication of centrifugally spun prepared poly(lactic acid)/gelatin/ciprofloxacin nanofibers for antimicrobial wound dressing
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Fabrication of centrifugally spun prepared poly(lactic acid)/gelatin/ciprofloxacin nanofibers for antimicrobial wound dressing

机译：离心旋转制备的聚（乳酸）/明胶/环丙沙昔甲酰胺纳米纤维用于抗微生物伤口敷料

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Centrifugal spinning is a novel technology for producing ultrafine fibers in high yield with diameters ranging from micro to nanometers. The obtained fibers have potential applications in the field of tissue engineering, wound dressing, and biomedicine etc. In this paper, a system of poly(lactic acid)/gelatin (PLA/GE) nanofibers loaded with ciprofloxacin (CPF) drug for wound dressings were successfully prepared by centrifugal spinning. The nanofibers were characterized by scanning electron microscopy (SEM) coupled with energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), thermal gravimetric analysis (TGA) and Fourier transform infrared spectroscopy (FTIR). In addition, the nanofibers' properties in terms of hydrophilicity, antibacterial properties and in vitro drug release were further investigated. The results showed that the CPF drug was successfully loaded and in an amorphous state in the PLA/GE nanofibers, the surface of the nanofibers was smooth and the nanofibers' diameter became large after the drug was loaded. The thermal stability of the nanofiber was reduced while the hydrophilicity was improved. Antibacterial and in vitro drug release experiments showed that the nanofibers have obvious antibacterial properties and have the positive effect of sustained release of the drug. Drug-loaded PLA/GE nanofibers could be good candidates for wound dressing.
机译：离心式纺丝是一种新的技术，用于生产高产率的超细纤维，直径从微量到纳米。所获得的纤维在组织工程，伤口敷料和生物医学等领域具有潜在的应用。本文中，一种用CIProfloxacin（CPF）药物用于伤口敷料的聚（乳酸）/明胶（PLA / GE）纳米纤维的系统通过离心纺丝成功制备。通过扫描电子显微镜（SEM）与能量分散光谱（EDS），X射线衍射（XRD），热重分析（TGA）和傅里叶变换红外光谱（FTIR）耦合耦合电子显微镜（SEM）。此外，进一步研究了纳米纤维的亲水性，抗菌性能和体外药物释放方面的性质。结果表明，CPF药物在PLA / GE纳米纤维中成功装载并在无定形状态下，纳米纤维的表面光滑，纳米纤维直径在装载药物后变大。减少了纳米纤维的热稳定性，同时改善了亲水性。抗菌和体外药物释放实验表明，纳米纤维具有明显的抗菌性能，并且具有持续释放药物的阳性效果。载药PLA / GE纳米纤维可能是伤口敷料的好候选人。

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    《RSC Advances》 |2019年第61期|共8页
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  • 正文语种 eng
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