Boron trifluoride etherate promoted microwave-assisted synthesis of antimalarial acridones

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Boron trifluoride etherate promoted microwave-assisted synthesis of antimalarial acridones

机译：硼三氟化醚酸乙酯促进微波辅助合成抗疟亚烷酮

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A microwave-assisted, rapid and efficient method using boron trifluoride etherate (BF3.Et2O) for the synthesis of acridones, via an intramolecular acylation of N-phenylanthranilic acid derivatives, has been developed. The reaction proceeds under solvent-free conditions, tolerates a wide range of functional groups, and provides rapid access to a range of acridones in good to excellent yields. Several of the synthesized acridones exhibited potent antimalarial activities against CQ sensitive and multi-drug resistant (MDR) parasites.

机译：已经开发了通过硼三氟化醚酯（BF3.ET2O）的微波辅助，快速，有效的方法，用于通过N-苯壬酸衍生物的分子内酰化合成吖啶酮。反应在无溶剂条件下进行，可耐受各种官能团，并提供良好的一系列吖啶，优异的产率。一些合成的吖啶含有针对CQ敏感和多药物抗性（MDR）寄生虫的有效的抗疟疾活动。

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《RSC Advances》 |2019年第72期|共10页
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1. Boron trifluoride etherate promoted microwave-assisted synthesis of antimalarial acridones [J] . RSC Advances . 2019,第72期

机译：硼三氟化醚酸乙酯促进微波辅助合成抗疟亚烷酮
2. An efficient synthesis of (+)-aureol via boron trifluoride etherate-promoted rearrangement of (+)-arenarol [J] . Masahiko Nakamura, Akiyuki Suzuki, Mari Nakatani, Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2002,第39期

机译：通过三氟化硼醚化物促进的（+）-芳烃的重排有效合成（+）-aureol
3. Boron trifluoride-etherate mediated synthesis of 3-desoxyanthocyanidins including a total synthesis of tricetanidin from black tea [J] . Nikolai Kuhnert, Mike N.Clifford, Anne-Gaelle Radenac Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2001,第52期

机译：三氟化硼-醚酸酯介导的3-脱氧花青素的合成，包括从红茶中完全合成tricetanidin
4. Boron trifluoride etherate-a mild and inexpensive reagent for synthesis of coumarin derivatives under solvent-free conditions [C] . Gaojun Sun, Zhiyong Wang, Manhua Chen International Conference on Future Materials Engineering and Industry Application . 2012

机译：硼三氟化醚酯 - 一种温和和廉价的试剂，用于在无溶剂条件下合成香豆素衍生物
5. Studies in synthetic organic chemistry: Part I. The synthesis of novel antimalarial artmeisinin dimers. Part II. Electronically stabilized versions of antimalarial acetal trioxanes. Part III. Novel analogs of natural hormone 1-alpha, 25-dihdroxyvitamin D3: Design, synthesis and biological evaluation of CYP24 inhibitors. Part IV. New silicon mediated ring expansions of N-sized 2-cycloalkenones into homoallylic N+3 sized lactones. [D] . Kalinda, Alvin Solomon. 2009

机译：合成有机化学研究：第一部分。新型抗疟药青蒿素二聚体的合成。第二部分电子稳定版的抗疟缩醛三恶烷。第三部分天然激素1-α，25-二羟维生素D3的新型类似物：CYP24抑制剂的设计，合成和生物学评估。第四部分新的硅介导的N尺寸的2-环烯酮的环扩环成均烯丙基N + 3尺寸的内酯。
6. The O- Acylation of Ketone Enolates by Allyl 1H-imidazole-1-carboxylate Mediated with Boron Trifluoride Etherate---A Convenient Procedure for the Synthesis of Substituted Allyl Enol Carbonates [O] . Barry M. Trost, Jiayi Xu -1

机译：三氟硼酸乙酯介导的1H-咪唑-1-羧酸烯丙基酯对烯醇酸酯的O-酰化反应-合成烯丙基烯醇碳酸酯的简便方法
7. Boron trifluoride etherate in organic synthesis [O] . Ajoy K Banerjee 2019

机译：硼三氟化醚酸乙酯在有机合成中
8. Reaction of 1,exo-5-Dimethyl-3-oxo-exo-6-Carbomethoxy-tricyclo(5.2.1.0(2,6)dec-8- ene) with Ethanedithiol in the Presence of Boron Trifluoride Etherate. A Novel Fragmentation Process. [R] . Marchand, A. P., Vidyasagar, V., Suri, S. C., 1989

机译：在三氟化硼醚合物存在下，1，外-5-二甲基-3-氧代 - 外-6-甲氧基 - 三环（5.2.1.0（2,6）癸-8-烯）与乙二硫醇反应。一种新的破碎过程。

Boron trifluoride etherate promoted microwave-assisted synthesis of antimalarial acridones

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