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首页> 外文期刊>RSC Advances >Poly(norepinephrine)-coated FeOOH nanoparticles as carriers of artemisinin for cancer photothermal-chemical combination therapy
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Poly(norepinephrine)-coated FeOOH nanoparticles as carriers of artemisinin for cancer photothermal-chemical combination therapy

机译：聚（Norepinephrine）涂料的FeOOH纳米粒子作为丙氨酸携带者的胰岛素，用于癌症光热化学组合治疗

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摘要

The photothermal-chemical combination therapy is a promising approach for cancer treatment, however, chemotherapy often causes severe toxic and side effects on normal tissues. Herein, tumor-specific FeOOH@PNE-Art nanoparticles were fabricated via coating poly(norepinephrine) (PNE) on FeOOH nanoparticles, followed by loading of artemisinin (Art). The as-prepared nanoparticles exhibited excellent biocompatibility, strong near-infrared (NIR) absorbance and pH-responsive synchronous release of Art and iron ions. The released iron ions could not only supply iron ions in cancer cells which mediate endoperoxide bridge cleavage of Art and generate reactive oxygen species (ROS), but also react with H2O2 at tumour sites via the Fenton reaction and produce hydroxyl radicals, inducing a tumour-specific killing. Moreover, owing to the synchronous release of Art and iron ions as well as the low leakage of iron ions, FeOOH@PNE-Art nanoparticles showed extremely low toxicity to normal tissue. Under NIR light irradiation, the tumours in FeOOH@PNE-Art injected mice were thoroughly eliminated after 7 days of treatment and no tumour recurrence was found 30 days after treatment, manifesting very high efficacy of combination therapy.
机译：光热化学组合疗法是癌症治疗的有希望的方法，但是化疗常常对正常组织产生严重的毒性和副作用。在此，通过在FeOOH纳米颗粒上涂覆聚（Norepinephrine）（PNE）来制造肿瘤特异性FeOOH @ Pne-Art纳米颗粒，然后加载氨化蛋白（ART）。制备的纳米颗粒具有优异的生物相容性，近红外（NIR）的近红外（NIR）吸光度和PH-响应的艺术和铁离子同步释放。释放的铁离子不仅可以在癌细胞中供应铁离子，该癌细胞介导内透氧化物桥裂解的艺术和产生反应性氧物质（ROS），而且还通过芬顿反应在肿瘤位点处与H 2 O 2反应并产生羟基自由基，诱导肿瘤 - 具体杀戮。此外，由于艺术和铁离子的同步释放以及铁离子的低渗漏，FeOOH @ Pne-Art纳米粒子对正常组织显示出极低的毒性。在Nir光照射下，在治疗7天后，FeOOH @ Pne-Art注射小鼠的肿瘤彻底消除，治疗后30天未发现肿瘤复发，表现出非常高的联合治疗疗效。

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  • 来源
    《RSC Advances》 |2019年第18期|共15页
  • 作者

    He Zi; Su Huiling; Shen Yuqing; Shi Wei; Liu Xin; Liu Yang; Zhang Fuhui; Zhang Yansheng; Sun Yanan; Ge Dongtao;

  • 作者单位

    Xiamen Univ Key Lab Biomed Engn Fujian Prov Univ Res Ctr Biomed Engn Xiamen Dept Biomat Coll Mat Xiamen 361005 Peoples R China;

    Xiamen Univ Key Lab Biomed Engn Fujian Prov Univ Res Ctr Biomed Engn Xiamen Dept Biomat Coll Mat Xiamen 361005 Peoples R China;

    Xiamen Maternal &

    Child Hlth Hosp Xiamen 361003 Peoples R China;

    Xiamen Univ Key Lab Biomed Engn Fujian Prov Univ Res Ctr Biomed Engn Xiamen Dept Biomat Coll Mat Xiamen 361005 Peoples R China;

    Xiamen Univ Key Lab Biomed Engn Fujian Prov Univ Res Ctr Biomed Engn Xiamen Dept Biomat Coll Mat Xiamen 361005 Peoples R China;

    Xiamen Univ Key Lab Biomed Engn Fujian Prov Univ Res Ctr Biomed Engn Xiamen Dept Biomat Coll Mat Xiamen 361005 Peoples R China;

    Xiamen Maternal &

    Child Hlth Hosp Xiamen 361003 Peoples R China;

    Xiamen Maternal &

    Child Hlth Hosp Xiamen 361003 Peoples R China;

    Xiamen Univ Key Lab Biomed Engn Fujian Prov Univ Res Ctr Biomed Engn Xiamen Dept Biomat Coll Mat Xiamen 361005 Peoples R China;

    Xiamen Univ Key Lab Biomed Engn Fujian Prov Univ Res Ctr Biomed Engn Xiamen Dept Biomat Coll Mat Xiamen 361005 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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