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Dual-mode US/MRI nanoparticles delivering siRNA and Pt(iv) for ovarian cancer treatment

机译：双模US / MRI纳米粒子递送siRNA和Pt（IV）用于卵巢癌治疗

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As known to all, ovarian cancer ranks the most lethal of the gynecological malignancies. The antitumor drugs based on platinum are first-line chemotherapy drugs for ovarian cancer. However, their therapeutic efficiency is severely limited owing to dose-limiting toxicities of platinum. New theranostic strategies to overcome chemotherapy toxicity is highly desirable. Meanwhile, the real-time treating effect is not visible for doctors. Herein, we constructed PFH/siRNA/Fe3O4@Pt(iv) NPs-cRGD (NPs-cRGD) for precise theranostics against ovarian tumors with real-time imaging. The NPs-cRGD had a good storage stability and resisted the serum-induced aggregation, which was beneficial for drug delivery. Additionally, gel-retardation assay demonstrated that the NPs-cRGD exhibited great protection to siRNA to resist nuclease degradation. In vitro, the NPs-cRGD showed good dual-mode US/MRI imaging and the relative imaging research was also discussed. Moreover, the in vitro experiments indicated that the NPs-cRGD with US exhibited excellent antitumor therapeutic efficiency, resulting from the cRGD ligands and US exposure enhanced the cellular uptake efficiency. Thus, the dual-mode nanoparticles in this work may provide precious insight into the development of various multi-mode nanoplatforms delivering drugs or genes for precise theranostics against various cancer.
机译：众所周知，卵巢癌是妇科恶性肿瘤的最致命性。基于铂金的抗肿瘤是卵巢癌的一线化疗药物。然而，由于铂的剂量限制毒性，它们的治疗效率严重限制。克服化疗毒性的新的治疗策略是非常理想的。同时，医生不可见实时治疗效果。在此，我们构建了PFH / siRNA / Fe3O4 @ Pt（IV）NPS-CRGD（NPS-CRGD），用于患有实时成像的卵巢肿瘤的精确治疗。 NPS-CRGD具有良好的储存稳定性并抵抗血清诱导的聚集，这有利于药物递送。另外，凝胶延迟测定证明NPS-CRGD对siRNA具有极大的保护，以抵抗核酸酶降解。体外，NPS-CRGD显示出良好的双模US / MRI成像，还讨论了相对成像研究。此外，体外实验表明，与美国的NPS-CRGD具有优异的抗肿瘤治疗效率，由CRGD配体和美国暴露产生增强的细胞吸收效率。因此，这项工作中的双模纳米颗粒可以珍贵地深入了解赋予各种多模纳薄表的发展，用于递送药物或基因的精确治疗各种癌症。

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    《RSC Advances》 |2019年第57期|共8页
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  • 正文语种 eng
  • 中图分类 化学;
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