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A real-time ratiometric fluorescent probe for imaging of SO2 derivatives in mitochondria of living cells

机译：用于活细胞线粒体中SO2衍生物成像的实时比率荧光探针

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摘要

A real-time ratiometric fluorescent probe (IN-CZ) for highly selective detection of sulfite was designed and synthesized, which is based on modulating the intramolecular charge transfer (ICT) of the hemicyanine dye platform. The mechanism of using the probe is mainly through the Michael addition that occurs between IN-CZ and sulfite with a detection limit of 2.99 x 10(-5) M. IN-CZ displays a fast response (within 1 minute) and is highly selective for SO32-/HSO3- over ROS, biologically relevant ions, biological mercaptans and other reactive species. More importantly, IN-CZ was suitable for ratiometric fluorescence imaging in living cells, by real-time monitoring of SO32-/HSO3- changes in mitochondria targeted in living cells.
机译：设计并合成了用于高度选择性检测的实时比率荧光探针（CZ），基于调节血清华染料平台的分子内电荷转移（ICT）。 使用探针的机制主要是通过在CZ和亚硫酸盐之间发生的迈克尔添加，检测限为2.99×10（-5）M. IN-CZ显示快速响应（1分钟内）并且是高度选择性的 对于SO32- / HSO3-过度，生物学相关离子，生物硫醇和其他反应性物种。 更重要的是，在-CZ中适用于活细胞中的比例荧光成像，通过对活细胞靶向线粒体的SO32- / HSO3-变化的实时监测。

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  • 来源
    《RSC Advances》 |2019年第39期|共7页
  • 作者

    Shi Junwei; Shu Wei; Tian Yong; Wu Yulong; Jing Jing; Zhang Rubo; Zhang Xiaoling;

  • 作者单位

    Beijing Inst Technol Sch Chem &

    Chem Engn Beying Key Lab Photoelect Electrophoton Convers M Key Lab Cluster Sci Minist Educ Beijing 100081 Peoples R China;

    Beijing Inst Technol Sch Chem &

    Chem Engn Beying Key Lab Photoelect Electrophoton Convers M Key Lab Cluster Sci Minist Educ Beijing 100081 Peoples R China;

    Beijing Inst Technol Sch Chem &

    Chem Engn Beying Key Lab Photoelect Electrophoton Convers M Key Lab Cluster Sci Minist Educ Beijing 100081 Peoples R China;

    Beijing Inst Technol Sch Chem &

    Chem Engn Beying Key Lab Photoelect Electrophoton Convers M Key Lab Cluster Sci Minist Educ Beijing 100081 Peoples R China;

    Beijing Inst Technol Sch Chem &

    Chem Engn Beying Key Lab Photoelect Electrophoton Convers M Key Lab Cluster Sci Minist Educ Beijing 100081 Peoples R China;

    Beijing Inst Technol Sch Chem &

    Chem Engn Beying Key Lab Photoelect Electrophoton Convers M Key Lab Cluster Sci Minist Educ Beijing 100081 Peoples R China;

    Beijing Inst Technol Sch Chem &

    Chem Engn Beying Key Lab Photoelect Electrophoton Convers M Key Lab Cluster Sci Minist Educ Beijing 100081 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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