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Niclosamide encapsulated polymeric nanocarriers for targeted cancer therapy

机译：Niclosamide包封聚合物纳米载体用于靶向癌症治疗

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Localized cancer rates are on an upsurge, severely affecting mankind across the globe. Timely diagnosis and adopting appropriate treatment strategies could improve the quality of life significantly reducing the mortality and morbidity rates. Recently, nanotherapeutics has precipitously shown increased efficacy for controlling abnormal tissue growth in certain sites in the body, among which ligand functionalized nanoparticles (NP) have caught much attention for improved survival statistics via active targeting. Our focus was to repurpose the antihelminthic drug, niclosamide (NIC), which could aid in inhibiting the abnormal growth of cells restricted to a specific region. The work here presents a one-pot synthesis of niclosamide encapsulated, hyaluronic acid functionalized core-shell nanocarriers [(NIC-PLGA NP)HA] for active targeting of localized cancer. The synthesized nanocarriers were found to possess spherical morphology with mean size of 150.8 +/- 9 nm and zeta potential of -24.9 +/- 7.21 mV. The encapsulation efficiency was found to be 79.19 +/- 0.16% with a loading efficiency of 7.19 +/- 0.01%. The nanohybrids exhibited extreme cytocompatibility upon testing with MDA-MB-231 and L929 cell lines. The rate of cancer cell elimination was approximately 85% with targeted cell imaging results being highly convincing. [(NIC-PLGA NP)HA] demonstrates increased cellular uptake leading to a hike in reactive oxygen species (ROS) generation, combating tumour cells aiding in the localized treatment of cancer and associated therapy.
机译：本地化的癌症率是在全球范围内严重影响人类的高潮。及时诊断和采用适当的治疗策略可以提高生活质量，显着降低死亡率和发病率。近来，纳米治疗剂急剧显示了对体内某些部位的异常组织生长的疗效增加，其中配体官能化纳米颗粒（NP）通过活性靶向改善存活统计数据。我们的重点是将抗骨蛋白（Niclosamide（NIC）的重点定治，这有助于抑制限制在特定区域的细胞的异常生长。这里的作品呈现了一种透明质酸透明质酸官能化核心壳纳米载体[（NIC-PLGA NP）HA]的单罐合成，用于局部癌症的活性靶向。发现合成的纳米载体具有球形形态，平均尺寸为150.8 +/- 9nm和-24.9 +/- 7.21 mV的Zeta电位。发现封装效率为79.19 +/- 0.16％，负载效率为7.19 +/- 0.01％。在用MDA-MB-231和L929细胞系进行测试时，纳米次次组表现出极端的细胞势。癌细胞消除率约为85％，具有靶细胞成像结果高度令人信服。 [（NIC-PLGA NP）HA]证明了在活性氧物质（ROS）产生中的蜂窝摄取增加，肿瘤细胞消除在癌症和相关治疗的局部治疗中。

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    《RSC Advances》 |2019年第46期|共10页
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  • 正文语种 eng
  • 中图分类 化学;
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