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首页> 外文期刊>RSC Advances >Cholesterol-coated gold nanorods as an efficient nano-carrier for chemotherapeutic delivery and potential treatment of breast cancer: in vitro studies using the MCF-7 cell line
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Cholesterol-coated gold nanorods as an efficient nano-carrier for chemotherapeutic delivery and potential treatment of breast cancer: in vitro studies using the MCF-7 cell line

机译：胆固醇涂覆的金纳米棒作为一种高效的纳米载体，用于化学治疗性输送和乳腺癌潜在治疗：使用MCF-7细胞的体外研究

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Gold nanorods (GNRs) have a recognized role in treatment of cancers as efficient nanocarriers for chemotherapeutic drug delivery. In this study, GNRs modified with cholesterol-PEG were employed as a nanocarrier for a hydrophobic compound having a promising phosphatidylinositol 3-kinase (PI3K) inhibitory activity. The acquired nanocomplex was characterized by optical and infra-red (IR) absorption spectroscopies, in addition to hydrodynamic size and zeta potential. Glide docking and superposing of docked poses of the hydrophobic ligand and cholesterol moiety demonstrated that hydrophobic interactions drive the conjugation and attachment of the ligand to the cholesterol moiety of the nanocarrier. In vitro release study under a cellular environment indicates that the presence of cells has enhanced the release and the cellular uptake of the conjugated ligand. Furthermore, the anti-proliferative assay of the nanocomplex revealed potent cytotoxicity over a low concentration range of the nanocomplex against MCF-7 breast cancer cells compared to the free compound or the nanocarrier alone. Analysis of cellular death modality by flow cytometry showed that the nanocomplex has a rapid effect on cell death, as cells went toward the late apoptotic/necrotic stage rapidly and proportionally to the increase of the nanocomplex concentration. The overall results propose that cholesterol-decorated GNRs could be considered as a promising nanocarrier for hydrophobic drugs to achieve efficient delivery and potential therapy against breast cancer cells.
机译：金纳米棒（GNRS）具有识别的作用，治疗癌症作为化学治疗药物递送的高效纳米载体。在该研究中，用胆固醇-PEG改性的GNRS作为疏水化合物的纳米载体，其具有有前途的磷脂酰肌醇3-激酶（PI3K）抑制活性。除了流体动力学尺寸和ζ电位之外，通过光学和红外线（IR）吸收光谱的特征在于，所获得的纳米键合。滑翔对接和疏水性配体和胆固醇部分的叠加的叠加证明了疏水相互作用使配体与纳米载体的胆固醇部分的共轭和连接。在细胞环境下的体外释放研究表明细胞的存在增强了缀合配体的释放和细胞吸收。此外，与单独的单独的单独的化合物或纳米载体相比，纳米麦络合物的抗增殖测定揭示了纳米核糖酰上的低浓度范围内的纳米麦单晶的低浓度范围内的细胞毒性。通过流式细胞术分析细胞死亡模态的分析表明，纳米麦络合物对细胞死亡具有快速影响，因为细胞迅速朝向晚期凋亡/坏死阶段，以比例地达到纳米键液的增加。整体结果提出胆固醇装饰的GNR可以被认为是疏水药物的有希望的纳米载体，以实现有效的递送和潜在治疗乳腺癌细胞。

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