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Self-assembly of l-phenylalanine amino acid: electrostatic induced hindrance of fibril formation

机译：L-苯丙氨酸氨基酸的自组装：静电诱导的原纤维形成障碍

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摘要

Nanostructure morphology originating from the self-assembly of molecules has attracted substantial attention due to its role in toxic amyloid fibril formation and immense potential in the design and fabrication of novel biomaterials. This study presents the role of intermolecular electrostatic interaction on the self-assembly process of l-phenylalanine (L-Phe) amino acid. We have employed attenuated total reflection Fourier transform infrared spectroscopy to probe the existence of different ionization states of the amino acid in various pH aqueous solutions. The self-assembly process of L-Phe in the aqueous phase is explored by using circular dichroism absorption and nuclear magnetic resonance spectroscopic tools. The observed spectral features have shown the signature of higher order structures and possible perturbation in the - stacking aromatic interactions for the cationic and anionic states of the amino acid. Scanning electron microscopy is used to probe the self-assembled morphology of the L-Phe amino acid dried samples prepared from the same pH aqueous solutions. We find that for the case of zwitterionic states the self-assembly nanostructures are dominated by the presence of fibrillar morphology, however interestingly for cationic and anionic states the morphology is dominated by the presence of flakes. Our finding demonstrates the potential influence of intermolecular electrostatic interaction over the aromatic - stacking interaction in hindering the fibril formation.
机译：源自分子自组装的纳米结构形态由于其在毒性淀粉样蛋白原纤维形成和巨大潜力在设计和制造新的生物材料中的作用而引起了大量的关注。该研究呈现了分子间静电相互作用对L-苯丙氨酸（L-PHE）氨基酸的自组装过程的作用。我们使用衰减的全反射傅里叶变换红外光谱，以探测各种pH水溶液中氨基酸的不同电离状态的存在。通过使用圆形二色吸收和核磁共振光谱工具探索水相中L-PHE的自组装过程。所观察到的光谱特征已经显示出高阶结构的签名以及氨基酸的阳离子和阴离子状态的堆积芳族相互作用的刺激。扫描电子显微镜用于探测由相同pH水溶液制备的L-PHE氨基酸干燥样品的自组装形态。我们发现，对于两性离子状态的情况，自组装纳米结构是由纤维状形态的存在主导的，然而有趣地对阳离子和阴离子状态的形态通过薄片的存在来占主导地位。我们的发现表明了分子间静电相互作用对静纤维堆叠相互作用的潜在影响阻碍原纤维形成。

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  • 来源
    《RSC Advances》 |2019年第22期|共10页
  • 作者

    Tomar Deepak; Chaudhary Shilpi; Jena Kailash Chandra;

  • 作者单位

    Indian Inst Technol Ropar Dept Phys Rupnagar 140001 Punjab India;

    Indian Inst Technol Ropar Dept Phys Rupnagar 140001 Punjab India;

    Indian Inst Technol Ropar Dept Phys Rupnagar 140001 Punjab India;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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