• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Current and future functional imaging techniques for post-traumatic stress disorder
【24h】

Current and future functional imaging techniques for post-traumatic stress disorder

机译：后创伤后应激障碍的电流和未来功能成像技术

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Posttraumatic stress disorder (PTSD) is a trauma and stressor related psychiatric disorder associated with structural, metabolic, and molecular alternations in several brain regions including diverse cortical areas, neuroendocrine regions, the striatum, dopaminergic, adrenergic and serotonergic pathways, and the limbic system. We are in critical need of novel therapeutics and biomarkers for PTSD and a deep understanding of cutting edge imaging and spectroscopy methods is necessary for the development of promising new approaches to better diagnose and treat the disorder. According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) criterion, all forms of traumatic stress-induced disorder are considered acute stress disorder for the first month following the stressor. Only after symptoms do not remit for one month can the disorder be deemed PTSD. It would be particularly useful to differentiate between acute stress disorder and PTSD during the one month waiting period so that more intensive treatments can be applied early on to patients with a high likelihood of developing PTSD. This would potentially enhance treatment outcomes and/or prevent the development of PTSD. Comprehension of the qualities and limitations of currently applied methods as well as the novel emerging techniques provide invaluable knowledge for fast paced development. Conventional methods of studying PTSD have proven to be insufficient for diagnosis, measurement of treatment efficacy, and monitoring disease progression. As the field currently stands, there is no diagnostic biomarker available for any psychiatric disease, PTSD included. Currently, emerging and available technologies are not utilized to their full capacity and in appropriate experimental designs for the most fruitful possible studies in this area. Therefore, there is an apparent need for improved methods in PTSD research. This review demonstrates the current state of the literature in PTSD, including molecular, cellular, and behavioral indicators, possible biomarkers and clinical and pre-clinical imaging techniques relevant to PTSD, and through this, elucidate the void of current practical imaging and spectroscopy methods that provide true biomarkers for the disorder and the significance of devising new techniques for future investigations. We are unlikely to develop a single biomarker for any psychiatric disorder however. As psychiatric disorders are incomparably complex compared to other medical diagnoses, its most likely that transcriptomic, metabolomic and structural and connectomic imaging data will have to be analyzed in concert in order to produce a dependable non-behavioral marker of PTSD. This can explain the necessity of bridging conventional approaches to novel technologies in order to create a framework for further discoveries in the treatment of PTSD.
机译：造成后的矫风障碍（PTSD）是一种创伤和压力源相关的精神疾病，其与结构，代谢和分子交替相关，包括多种皮质区域，神经内分泌区域，纹状体，多巴胺能，肾上腺素能和血管干燥途径和肢体系统。我们致力于对PTSD的新疗法和生物标志物进行了危急，并且对切削刃成像和光谱方法的深刻理解是开发有希望更好地诊断和治疗疾病的新方法是必要的。根据精神障碍（DSM-V）标准的诊断和统计手册，所有形式的创伤应激诱导的病症被认为是压力源之后的第一个月的急性应激障碍。只有在症状后才能延长一个月，疾病可被视为可行的目标。在一个月的等待期间，区分急性应激障碍和可行科目为特别有用，以便更加强化治疗可以早期应用于高可能发展PTSD的患者。这将可能提高治疗结果和/或预防应投灾的发展。理解目前应用方法的品质和局限性以及新兴技术的新兴技术为快节奏发展提供了宝贵的知识。学期的常规方法已被证明是不足以诊断，治疗疗效测量和监测疾病进展。作为目前的领域，没有任何精神病疾病的诊断生物标志物，包括在内的PTSD。目前，新兴和可用技术没有用于它们的全部能力，以及适当的实验设计，以获得该领域最富有成效的可能研究。因此，有明显需要改进的PTSD研究方法。该审查证明了PTSD中的文献现状，包括分子，细胞和行为指标，可能的生物标志物和与PTSD相关的临床和临床前成像技术，并通过这一点，阐明了当前实际成像和光谱方法的空隙为这种疾病提供真正的生物标志物，并为未来调查设计新技术的重要性。然而，我们不太可能为任何精神疾病开发单一生物标志物。与其他医学诊断相比，精神病疾病无比复杂，其最有可能以音乐会分析转录组，代谢组和结构和克彻癌成像数据，以产生可靠的应激障碍的非行为标志物。这可以解释拓展新技术促进传统方法的必要性，以便在治疗PTSD的治疗中创造进一步发现的框架。

著录项

  • 来源
    《RSC Advances》 |2019年第42期|共27页
  • 作者

  • 作者单位
  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号