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首页> 外文期刊>RSC Advances >Ultra-small bimetallic iron-palladium (FePd) nanoparticle loaded macrophages for targeted tumor photothermal therapy in NIR-II biowindows and magnetic resonance imaging
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Ultra-small bimetallic iron-palladium (FePd) nanoparticle loaded macrophages for targeted tumor photothermal therapy in NIR-II biowindows and magnetic resonance imaging

机译：超小型双金属铁 - 钯（FEPD）纳米粒子加载巨噬细胞用于NIR-II生物鹬和磁共振成像的靶向肿瘤光热疗

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Nanoparticles working in the NIR-II biowindows possess larger maximum permissible exposure (MPE) and desirable penetration depth to the laser. However, most NIR-II responsive nanomaterials lack tumor targeting and Magnetic Resonance Imaging (MRI) ability. This greatly limits their applications. This study reported ultra-small bimetallic iron-palladium (FePd) nanoparticle loaded macrophages for targeted tumor photothermal therapy in NIR-II biowindows and magnetic resonance imaging. The crystal phase, morphology, absorption spectrum and photothermal performance of the synthesized samples were systematically characterized. The effects of photothermal therapy and nuclear magnetic imaging (MRI) were studied both in vitro and in vivo. Since FePd nanoparticles have both iron and palladium elements, it had a good MRI imaging capability and high photothermal conversion efficiency (36.7%). After binding to macrophages, FePd nanoparticles@macrophages (FePd@M) showed a good tumor targeting ability and were used for targeting NIR-II photothermal therapy and MRI imaging of tumors. The results of photothermal treatment showed that the tumor volume decreased by 90% compared to the control group, and no significant organ toxicity was observed. The results of MRI imaging showed that the FePd@M has the best imaging effect. The nanoparticles with the excellent NIR-II PTT ability and MRI effect have overcome the problem of tumor targeting and avoid the rapid removal of ultra-small nanoparticles. The FePd@M delivery system provides new ideas for material construction in the NIR-II region and has great clinical application potential.
机译：在NIR-II BiOwindows中工作的纳米粒子具有更大的最大允许曝光（MPE）和激光所需的渗透深度。然而，大多数NIR-II响应性纳米材料缺乏肿瘤靶向和磁共振成像（MRI）能力。这大大限制了他们的应用。本研究报告了Ultra-Small-Smimetallic铁钯（FEPD）纳米颗粒加载巨噬细胞，用于靶向肿瘤光热疗法在NIR-II生物鹬和磁共振成像中。系统地表征了合成样品的晶相，形态，吸收光谱和光热性能。在体外和体内研究了光热疗和核磁成像（MRI）的影响。由于FEPD纳米颗粒具有铁和钯元件，因此它具有良好的MRI成像能力和高光热转化效率（36.7％）。在与巨噬细胞结合后，FEPD纳米颗粒@巨噬细胞（FEPD @ M）显示出良好的肿瘤靶向能力，用于靶向肿瘤的NIR-II光热疗和MRI成像。光热处理结果表明，与对照组相比，肿瘤体积降低了90％，并且没有观察到显着的器官毒性。 MRI成像的结果表明FEPD @ M具有最佳的成像效果。具有优异的NIR-II PTT能力和MRI效应的纳米颗粒克服了肿瘤靶向的问题，避免了超小纳米颗粒的快速去除。 FEPD @ M送货系统为NIR-II区域提供了新的材料建设的新思路，具有很大的临床应用潜力。

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    《RSC Advances》 |2019年第57期|共10页
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  • 正文语种 eng
  • 中图分类 化学;
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