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A comparison of the characteristics of polyurethane-based sealers including various antimicrobial agents

机译：基于聚氨酯的密封剂的特性进行比较，包括各种抗微生物剂

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摘要

An obturation biomaterial that possess inherent antibacterial activity has been developed to create a tight seal for the root canal space in treatment. Novel castor oil-based polyurethane sealers composited with different proportions of silver phosphate or zinc oxide nanoparticles were synthesized to investigate the physicochemical properties, antibacterial effect on Enterococcus faecalis, and cytotoxicity on murine fibroblasts compared with commercially available products. The results showed that the physical properties of all of the polyurethane sealers could meet with the standards expected. The microdilatancy character of the polyurethane sealers was particularly preferable for the three dimensional obturation of root canal space. Compared with the silver-loaded polyurethane series, the zinc-loaded polyurethane series showed better antibacterial properties based on the contact mode. Analysis of the kinetics indicated that the setting process of the polyurethane sealers supported a first-order reaction and the setting process was highly effective, with more than 90% of the isocyanate groups participating in the setting reaction within 12 h. This is beneficial for the rapid consumption of monomers, efficiently avoiding inflammation. The in vitro results showed that the polyurethane sealers loaded with zinc oxide nanoparticles or 1 wt% silver phosphate were desirable for cell attachment and proliferation compared with the commercial sealers. In conclusion, the castor oil-based polyurethane-zinc sealers, especially PU-Zn5, present good physicochemical and antibacterial properties and cytocompatibility, and could be a promising candidate for application in the field of root canal treatment.
机译：已经开发出具有固有的抗菌活性的闭膜生物材料以为治疗的根管空间产生紧密密封。合成了用不同比例的磷酸银或氧化锌纳米颗粒组成的新型蓖麻油基聚氨酯密封剂，以研究与市售产品相比的物理化学特性，对肠球菌对肠球菌的抗菌作用和细胞毒性。结果表明，所有聚氨酯密封剂的物理性质都可以与预期的标准相交。聚氨酯密封剂的微脱发性特征对于根管空间的三维粒子是特别优选的。与载镀银聚氨酯系相比，锌加载的聚氨酯系列基于接触模式显示出更好的抗菌性能。动力学的分析表明，聚氨酯密封剂的设定过程支持一阶反应，并且设定过程非常有效，具有超过90％的异氰酸酯基团参与12小时内的设定反应。这对单体的快速消耗有益，有效地避免炎症。与商业密封剂相比，体外结果表明，加载有氧化锌纳米颗粒或1wt％银磷酸盐的聚氨酯封口剂是为了细胞附着和增殖。总之，蓖麻油基聚氨酯 - 锌密封剂，尤其是PU-ZN5，具有良好的物理化学和抗菌性和细菌性，并且可以是在根管治疗领域应用的有希望的候选者。

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  • 来源
    《RSC Advances》 |2019年第13期|共14页
  • 作者

    Wang Jian; Mei Quanjing; Lin Lili; Sun Fuhua; Li Jidong; Zou Qin; Zuo Yi; Li Yubao;

  • 作者单位

    Sichuan Univ Analyt &

    Testing Ctr Res Ctr Nano Biomat Chengdu 610064 Sichuan Peoples R China;

    Sichuan Univ Analyt &

    Testing Ctr Res Ctr Nano Biomat Chengdu 610064 Sichuan Peoples R China;

    Sichuan Univ Analyt &

    Testing Ctr Res Ctr Nano Biomat Chengdu 610064 Sichuan Peoples R China;

    Sichuan Univ Analyt &

    Testing Ctr Res Ctr Nano Biomat Chengdu 610064 Sichuan Peoples R China;

    Sichuan Univ Analyt &

    Testing Ctr Res Ctr Nano Biomat Chengdu 610064 Sichuan Peoples R China;

    Sichuan Univ Analyt &

    Testing Ctr Res Ctr Nano Biomat Chengdu 610064 Sichuan Peoples R China;

    Sichuan Univ Analyt &

    Testing Ctr Res Ctr Nano Biomat Chengdu 610064 Sichuan Peoples R China;

    Sichuan Univ Analyt &

    Testing Ctr Res Ctr Nano Biomat Chengdu 610064 Sichuan Peoples R China;

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