Supramolecular gels from sugar-linked triazole amphiphiles for drug entrapment and release for topical application

Sharma Komal; Joseph Jojo P.; Sahu Adarsh; Yadav Narender; Tyagi Mohit; Singh Ashmeet; Pal Asish; Kartha K. P. Ravindranathan

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Supramolecular gels from sugar-linked triazole amphiphiles for drug entrapment and release for topical application

机译：来自糖连接的三唑两亲凝胶的超分子凝胶，用于药物夹带和局部应用的释放

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A simple molecular framework obtained by cross-linking a hydrophobic chain with S,S- and R,R-tetritol by the copper-catalysed azide-alkyne cycloaddition reaction is found to serve as an excellent bioisostere for self-assembly. The hexadecyl-linked triazolyl tetritol composite spontaneously self-assembles in n-hepane and methanol to form hierarchical organogels. Microscopic analyses and X-ray diffraction studies demonstrate eventual formation of nanotubes through lamellar assembly of the amphiphiles. A rheological investigation shows solvent-dictated mechanical properties that obey power law behavior similar to other low molecular weight gelators (LMOGs). The gel network was then utilized for the entrapment of drugs e.g. ibuprofen and 5-fluorouracil, with tunable mechanical behaviour under applied stress. The differential release profiles of the drugs over a period of a few hours as a result of the relative spatio-temporal location in the supramolecular network can be utilized for topical formulations.

机译：通过交联具有S，S-和R，R-丁糖醇由铜催化的叠氮化物 - 炔烃环加成反应的疏水性链获得一个简单的分子骨架是发现以作为自组装优异的生物电子等排。十六烷基联三唑丁糖醇复合自发正hepane和甲醇自组装，以形成分层的有机凝胶。显微镜分析和X射线衍射研究显示通过两亲物的层状组件最终形成的纳米管。流变学调查表明溶剂口述的机械性质类似的其他低分子量胶凝剂（LMOGs）服从幂律行为。然后将凝胶网络被用于药物例如包封布洛芬和5-氟尿嘧啶，与外加应力下可调谐机械行为。历时几个小时的超分子网络中的相对时空位置的结果，药物的差动释放曲线可用于局部制剂。

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《RSC Advances》 |2019年第34期|共9页
作者
Sharma Komal; Joseph Jojo P.; Sahu Adarsh; Yadav Narender; Tyagi Mohit; Singh Ashmeet; Pal Asish; Kartha K. P. Ravindranathan;
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NIPER Dept Med Chem Sas Nagar 160062 Punjab India;

Inst Nano Sci &

Technol Phase 10 Sect 64 Mohali 160062 Punjab India;

NIPER Dept Med Chem Sas Nagar 160062 Punjab India;

NIPER Dept Med Chem Sas Nagar 160062 Punjab India;

NIPER Dept Med Chem Sas Nagar 160062 Punjab India;

Inst Nano Sci &

Technol Phase 10 Sect 64 Mohali 160062 Punjab India;

Inst Nano Sci &

Technol Phase 10 Sect 64 Mohali 160062 Punjab India;

NIPER Dept Med Chem Sas Nagar 160062 Punjab India;

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中图分类化学;
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1. Supramolecular gels from sugar-linked triazole amphiphiles for drug entrapment and release for topical application [J] . Sharma Komal, Joseph Jojo P., Sahu Adarsh, RSC Advances . 2019,第34期

机译：来自糖连接的三唑两亲凝胶的超分子凝胶，用于药物夹带和局部应用的释放
2. Effect of hydrogen bonding and hydrophobicity on gel emulsions by benzenesulphonamide moiety-based amphiphiles: entrapment and release of vitamin B_(12) [J] . Sumita Roy, Byomkesh Kar, Siddhartha Das, Chemicke Zvesti . 2020,第8期

机译：苯磺胺基两亲物氢粘接与疏水性对凝胶乳液的影响：维生素B_（12）的涂层和释放
3. Effect of pH and amphiphile concentration on the gel-emulsion of sodium salt of 2-dodecylpyridine-5-boronic acid: Entrapment and release of vitamin B_(12) [J] . Monali Maiti, Aparna Roy, Sumita Roy Colloids and Surfaces, A. Physicochemical and Engineering Aspects . 2014,第Null期

机译：pH和两亲物浓度对2-十二烷基吡啶-5-硼酸钠盐凝胶乳液的影响：维生素B_（12）的截留和释放
4. Tunable Small-Molecule Drug Release from Peptide-Amphiphile Supramolecular Polymers [C] . John B. Matson, Samuel I. Stupp PMSE Symposia . 2011

机译：从肽 - 两亲的超分子聚合物可调谐小分子药物释放
5. Heparin-binding peptide amphiphile supramolecular architectures as platforms for angiogenesis and drug delivery. [D] . Chow, Lesleyann W. 2009

机译：肝素结合肽两亲性超分子结构作为血管生成和药物递送的平台。
6. Nanostructure-templated control of drug release from peptide amphiphile nanofiber gels [O] . John B. Matson, Christina J. Newcomb, Ronit Bitton, -1

机译：从肽两亲物纳米纤维凝胶药物释放的纳米结构的模板化控制
7. Electro-responsive weight change and the application to controlled release of drug in polyelectrolyte gel entrapping natural polysaccharide. [O] . Kouichi Sutani, Isao Kaetsu, Kumao Uchida, 2001

机译：电响应重量变化及其在聚电解质凝胶中控制释放的应用诱捕自然多糖。

Supramolecular gels from sugar-linked triazole amphiphiles for drug entrapment and release for topical application

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