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Harnessing platelets as functional vectors for contrast enhanced ultrasound imaging and fluorescence imaging

机译：利用血小板作为功能载体，用于对比增强超声成像和荧光成像

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The recent progress in the development of highly biocompatible nanoplatforms mostly encompasses the use of biological excipients such as red blood cells, cancer cell membranes, and also platelets. Such specialized vectors, if mimicked correctly, have intrinsic ability to navigate through the biological system and perform their intended action without eliciting any cascade of inflammatory processes. Naturally, platelets have been found to accumulate in the wound sites and also interact with circulating tumor cells (CTCs). Inspired by the targeting ability of platelets and the clinical success of ultrasound, herein we developed a novel ultrasound contrast agent (UCA) by backfilling of an insoluble gas into the platelets after lyophilization ex vivo. The as-prepared platelet-based ultrasound contrast agent (P-UCA) disguised the structural integrity of the natural platelets with an average diameter of 3.1 +/- 0.4 mu m, and could enhance the ultrasound signal both in vitro and in vivo. Besides, we further evaluated that such platelet particles could facilitate active loading of ICG molecules for prolonged in vivo fluorescence imaging compared to the free ICG. Taking all the results together, we established that biological structures such as platelets could be repurposed ex vivo as a"shell" to encapsulate gas and be further extended to load ICG for real-time ultrasound and fluorescence imaging respectively. This not only indicates many potential uses of these MBs in the diagnosis of platelet-related diseases, such as vascular damage, thrombosis, and atherosclerosis, but also serves as a powerful platform with multimodal theranostic capability after active loading of a variety of therapeutic and diagnostic agents.
机译：最近在高度生物相容性纳米型纳米片的发展的进展主要包括使用生物赋形剂，例如红细胞，癌细胞膜和血小板。这种专业载体（如果正确地模仿），具有透过生物系统的内在能力，并且在不引出任何炎症过程的情况下进行预期动作。当然，已经发现血小板积聚在伤口位点，也与循环肿瘤细胞（CTC）相互作用。灵感来自血小板的靶向能力和超声的临床成功，在本文中，我们通过在冻干之后通过在冻干之后将不溶气回填到血小板中的新型超声造影剂（UCA）开发了一种新的超声造影剂（UCA）。基于模拟的基于血小板的超声造影剂（P-UCA）伪装了平均直径为3.1 +/-0.4μm的天然血小板的结构完整性，并且可以在体外和体内增强超声信号。此外，我们进一步评估了与游离ICG相比，这种血小板颗粒可以促进ICG分子的主动加载，延长体内荧光成像。将所有结果一起携手共同，我们建立了血小板等生物结构可以作为“壳”作为“壳”来封装气体，进一步延伸以分别加载ICG以分别用于实时超声波和荧光成像。这不仅表明这些MBS在血小板相关疾病的诊断中的许多潜在用途，例如血管损伤，血栓形成和动脉粥样硬化，而且还用作在主动加载各种治疗和诊断后的多峰治疗能力的强大平台代理商。

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    《RSC Advances》 |2019年第72期|共7页
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  • 正文语种 eng
  • 中图分类 化学;
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