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首页> 外文期刊>RSC Advances >Tumour targeted contrast enhanced ultrasound imaging dual-modal microbubbles for diagnosis and treatment of triple negative breast cancer
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Tumour targeted contrast enhanced ultrasound imaging dual-modal microbubbles for diagnosis and treatment of triple negative breast cancer

机译：肿瘤靶向对比增强超声成像双重模态微泡用于诊断和治疗三重阴性乳腺癌

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摘要

At present, the treatment of triple negative breast cancer (TNBC) is a worldwide problem, urgently requiring early precise diagnosis and effective treatment methods. In our study, we designed a type of tumour targeted dual-modal microbubbles, paclitaxel (PTX)-loaded RGD-lipid microbubbles (PTX@ RGD-MBs), combined with ultrasonic targeted microbubble destruction (UTMD) to precisely diagnose TNBC and to improve the curative effect. As the first-line drug, PTX, lacking specific tumour targeting and the ability to be effectively internalized by TNBC cells, is still not effective in killing TNBC cells. For this reason, we used the tumour active targeting peptide RGD to precisely guide MBs around TNBC cells through the high affinity to the integrin avb3 receptor, and use UTMD to generate shear stress on cells to open transient pores in the cellular membrane, so as to improve MB penetration into the cellular membrane. Sulfur hexafluoride (SF6) as the internal gas of MBs can greatly improve the resolution and sensitivity of conventional US images through nonlinear harmonics to enhance the comparison between lesions and surrounding normal tissues. The results in our study demonstrated that RGD-MBs with UTMD were internalized by TNBC cells more effectively, leading to significant increase in intercellular drug concentrations of TNBC cells, thus achieving the best inhibitory effect on TNBC cells in vitro. Ultrasonic experiment showed that PTX@ RGD-MBs produced high quality contrast enhanced ultrasound (CEUS) images in vitro and in vivo, providing a better method for diagnosis and evaluation of the TNBC. Therefore, we conclude the advantages of excellent anti-tumour effect and CEUS imaging of PTX@ RGDMBs provided a better application for diagnosis and treatment of TNBC.
机译：目前，治疗三重阴性乳腺癌（TNBC）是全球问题，迫切需要早期精确的诊断和有效的治疗方法。在我们的研究中，我们设计了一种肿瘤靶向双型微泡，紫杉醇（PTX） - 加载的RGD-脂质微泡（PTX @ RGD-MBS），与超声波靶向微泡破坏（UTMD）结合，精确地诊断TNBC并改善疗效。作为第一线药物，缺乏特异性肿瘤靶向的PTX和通过TNBC细胞有效内化的能力，仍然无效地杀死TNBC细胞。出于这个原因，我们使用了肿瘤活性靶向肽RGD通过高亲和力精确地引导围绕TNBC细胞的MB与整avb3受体，并使用UTMD细胞上以打开瞬态产生的剪切应力的孔在细胞膜，以便将Mb渗透提高到细胞膜中。六氟化硫（SF6）随着MBS的内部气体，通过非线性谐波大大提高常规美国图像的分辨率和敏感性，以增强病变与周围正常组织之间的比较。我们研究的结果证明，具有UTMD的RGD-MBS由TNBC细胞更有效地内化，导致TNBC细胞细胞间药物浓度的显着增加，从而在体外实现了对TNBC细胞的最佳抑制作用。超声波试验表明，PTX @ RGD-MBS产生高质量超声造影（CEUS）在体外和体内的图像，提供用于TNBC的诊断和评价的较好方法。因此，我们得出优异的抗肿瘤效应和PTX @ RGDMBS的CEUS成像的优点为TNBC的诊断和治疗提供了更好的应用。

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  • 来源
    《RSC Advances》 |2019年第10期|共10页
  • 作者

    Bai Min; Dong Yang; Huang Hui; Fu Hao; Duan Yourong; Wang Qi; Du Lianfang;

  • 作者单位

    Shanghai Jiao Tong Univ Sch Med Shanghai Gen Hosp Dept Ultrasound Shanghai 200080 Peoples R China;

    Shanghai Jiao Tong Univ State Key Lab Oncogenes &

    Related Genes Shanghai Canc Inst Renji Hosp Sch Med Shanghai 200032 Peoples R China;

    Shanghai Jiao Tong Univ State Key Lab Oncogenes &

    Related Genes Shanghai Canc Inst Renji Hosp Sch Med Shanghai 200032 Peoples R China;

    Shanghai Jiao Tong Univ State Key Lab Oncogenes &

    Related Genes Shanghai Canc Inst Renji Hosp Sch Med Shanghai 200032 Peoples R China;

    Shanghai Jiao Tong Univ State Key Lab Oncogenes &

    Related Genes Shanghai Canc Inst Renji Hosp Sch Med Shanghai 200032 Peoples R China;

    East China Univ Sci &

    Technol Sch Chem &

    Mol Engn Key Lab Adv Mat Shanghai 200237 Peoples R China;

    Shanghai Jiao Tong Univ Sch Med Shanghai Gen Hosp Dept Ultrasound Shanghai 200080 Peoples R China;

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