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Bi-functional titanium-polydopamine-zinc coatings for infection inhibition and enhanced osseointegration

机译：双官能钛 - 聚二胺 - 锌涂料，用于感染抑制和增强的骨整合

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摘要

The ideal orthopedic implant coating is expected to both inhibit microbial infection and promote osseointegration. In this study, Zn ions were immobilized on a Ti substrate via a polydopamine (PDA) chemical surface modification to prepare Ti-PDA-Zn coatings. Scanning electron microscopy (SEM), atomic force microscopy (AFM), energy-dispersive X-ray spectroscope (EDS), X-ray photoelectron spectroscopy (XPS), contact analysis system, and inductively coupled plasma atomic emission spectrometry (ICP-AES) were used to analyze the morphology, composition, wettability, and zinc ions release of the coatings. The Ti-PDA-Zn coatings demonstrated excellent antibacterial activities in vitro against both Staphylococcus aureus and Escherichia coli. The coatings additionally displayed good biocompatibility, as confirmed by cytoskeletal observations and cell viability assays. Furthermore, the in vivo results confirmed the excellent antibacterial properties and improved osseointegration capability of the Ti-PDA-Zn coating in the presence of S. aureus. The present findings indicate that the Ti-PDA-Zn coatings prepared herein have potential application in orthopedic implantation.
机译：预计理想的整形外科涂层均均抑制微生物感染和促进骨整合。在该研究中，通过聚德胺（PDA）化学表面改性将Zn离子固定在Ti底物上以制备Ti-PDA-Zn涂层。扫描电子显微镜（SEM），原子力显微镜（AFM），能量分散X射线分光镜（EDS），X射线光电子体光谱（XPS），接触分析系统和电感耦合等离子体原子发射光谱（ICP-AES）用于分析涂层的形态，组成，润湿性和锌离子释放。 Ti-PDA-Zn涂层在体外展示了对金黄色葡萄球菌和大肠杆菌的优异抗菌活性。涂层另外显示出良好的生物相容性，如细胞骨骼观察和细胞活力测定的确认。此外，体内结果证实了在S.UUREUS存在下Ti-PDA-Zn涂层的优异抗菌性能和改善的骨整合能力。本发明的研究结果表明，本文制备的Ti-PDA-Zn涂层在整形外科植入中具有潜在的应用。

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  • 来源
    《RSC Advances》 |2019年第6期|共14页
  • 作者

    Wang Lei; Shang Xifu; Hao Yuefeng; Wan Guoyang; Dong Lijun; Huang Degang; Yang Xin; Sun Junying; Wang Qiang; Zha Guochun; Yang Xing;

  • 作者单位

    Wannan Med Coll Affiliated Hosp 1 Dept Orthoped Wuhu 241001 Anhui Peoples R China;

    Univ Sci &

    Technol China Affiliated Hosp 1 Dept Orthoped Hefei 230001 Anhui Peoples R China;

    Nanjing Med Univ Affiliated Suzhou Hosp Dept Orthoped Suzhou 215500 Jiangsu Peoples R China;

    Nanjing Med Univ Affiliated Suzhou Hosp Dept Orthoped Suzhou 215500 Jiangsu Peoples R China;

    Wannan Med Coll Affiliated Hosp 1 Dept Orthoped Wuhu 241001 Anhui Peoples R China;

    Wannan Med Coll Affiliated Hosp 1 Dept Orthoped Wuhu 241001 Anhui Peoples R China;

    Wannan Med Coll Affiliated Hosp 1 Dept Orthoped Wuhu 241001 Anhui Peoples R China;

    Soochow Univ Affiliated Hosp 1 Dept Orthoped Suzhou 215000 Jiangsu Peoples R China;

    Wannan Med Coll Affiliated Hosp 1 Dept Orthoped Wuhu 241001 Anhui Peoples R China;

    Xuzhou Med Univ Affiliated Hosp Dept Orthoped Surg Xuzhou 221002 Jiangsu Peoples R China;

    Nanjing Med Univ Affiliated Suzhou Hosp Dept Orthoped Suzhou 215500 Jiangsu Peoples R China;

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