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首页> 外文期刊>RSC Advances >Anticancer and antimicrobial properties of novel eta(6)-p-cymene ruthenium(II) complexes containing a N,S-type ligand, their structural and theoretical characterization
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Anticancer and antimicrobial properties of novel eta(6)-p-cymene ruthenium(II) complexes containing a N,S-type ligand, their structural and theoretical characterization

机译：新的ETA（6）-p-cymene钌（II）配合物的抗癌和抗微生物性质含有N，S型配体，结构和理论表征

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Ruthenium(II) complexes are lately of great scientific interest due to their chemotherapeutic potential as anticancer and antimicrobial agents. Here we present the synthesis of new pyrazole carbothioamide derivatives and their four arene-ruthenium complexes. The title compounds were characterized with the application of IR, NMR, mass spectrometry, elemental analysis and X-ray diffraction. Additionally, for new complexes DFT calculations were done. Their antimicrobial activity (MIC, MBC/MFC) was examined in vitro against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Pseudomonas aeruginosa, Proteus vulgaris and Candida albicans. Their cytotoxic effects, using the MTT assay, against three cancer cell lines: HL-60, NALM-6, WM-115 and normal human foreskin fibroblasts (HFF-1) were also investigated. The influence of the new arene-ruthenium(II) complexes on the DNA structure was also tested. From our results, compound 2d showed higher cytotoxicity against melanoma cell line WM-115 than cisplatin. Strong biostatic and biocidal activity of the tested complexes against Gram-positive bacteria, including S. aureus, S. epidermidis and E. faecalis was demonstrated. The new arene-ruthenium(II) compounds could not only inhibit proliferation of cancer cells, but also protect patients against malignant wound infections.
机译：由于其化学治疗潜力作为抗癌和抗微生物剂，钌（II）复合物最良好的科学兴趣。在这里，我们介绍了新的吡唑碳磷酸衍生物及其四个芳烃 - 钌配合物的合成。标题化合物的特征在于IR，NMR，质谱，元素分析和X射线衍射。此外，对于新的复合物DFT计算完成。在体外检查它们的抗菌活性（MIC，MBC / MFC）对金黄色葡萄球菌，葡萄球菌，粪群，肠球菌Aeruginosa，Proteus Ventgaris和Candida albicans。还研究了使用MTT测定的细胞毒性效应，对抗三种癌细胞系：HL-60，NALM-6，WM-115和正常人包皮成纤维细胞（HFF-1）。还测试了新的芳烃 - 钌（II）复合物对DNA结构的影响。从我们的结果，化合物2D对黑色素瘤细胞系WM-115的细胞毒性比顺铂显示出更高的细胞毒性。证明了对革兰氏阳性细菌的测试复合物的强大的生物静态和生物灭菌活性，包括S. aureus，S.表皮和粪便。新的芳烯 - 钌（II）化合物不仅可以抑制癌细胞的增殖，而且还可以保护患者免受恶性伤口感染。

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    《RSC Advances》 |2019年第66期|共17页
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  • 正文语种 eng
  • 中图分类 化学;
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