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Insight into the DNA adsorption on nitrogen-doped positive carbon dots

机译：深入了解氮掺杂阳性碳点的DNA吸附

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摘要

Considerable biosensors have been fabricated on the basis of DNA interaction with carbon nanomaterials, such as graphene oxide (GO) nanosheets. Few studies have focused on the rational design of sensors between carbon dots (CDs) and DNA due to the limited understanding of the real forces behind the adsorption of DNA on CDs. In this work, nitrogen doping-positive CDs (N-CDs), which can quench fluorophore-labeled DNA, were investigated to ascertain the interaction between the CDs and DNA. With reference to DNA adsorption on GO, the adsorption capacity and kinetics of N-CDs for DNA were studied. Desorption of DNA from these surfaces was also measured. Moreover, DNA desorption and anchoring force of N-CDs to DNA were different from those of GO, given that the prepared N-CDs and GO were positively and negatively charged, respectively. Accordingly, DNA was adsorbed on N-CDs mainly via electrostatic adsorption and other forces, such as nucleobase effect, hydrophobic interaction, and van der Waals (vdW) forces. This study enhanced the basic knowledge of DNA adsorption on some CDs for further study in the application of CDs in bioanalysis or biomedicine.
机译：基于与碳纳米材料的DNA相互作用，如石墨烯（GO）纳米片，已经制造了相当大的生物传感器。少数研究专注于碳点（CDS）和DNA之间的传感器的合理设计，因为对CDS上DNA的吸附背后的真实力有关的有限理解。在这项工作中，研究了可以促进荧光团标记的DNA的氮掺杂阳性Cds（N-CD），以确定Cds和DNA之间的相互作用。参考DNA吸附ON GO，研究了N-CDS用于DNA的吸附能力和动力学。还测量了来自这些表面的DNA的解吸。此外，鉴于制备的N-CD和持续的N-CD和持续电荷，N-CD至DNA的DNA解吸和锚固力与DNA的DNA的锚固力不同。因此，主要通过静电吸附和其他力，例如核碱基效果，疏水相互作用和范德华（VDW）力，将DNA吸附在N-CD上。本研究提高了对某些CDS对某些CDS的基本知识进行进一步研究CDS在生物分析或生物医学中的应用。

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  • 来源
    《RSC Advances》 |2019年第22期|共8页
  • 作者

    Li Fenglan; Cai Qianqian; Hao Xiaoli; Zhao Chengfei; Huang Zhengjun; Zheng Yanjie; Lin Xinhua; Weng Shaohuang;

  • 作者单位

    Fujian Med Univ Sch Pharm Dept Pharmaceut Anal Fuzhou 350122 Fujian Peoples R China;

    Fujian Med Univ Sch Pharm Dept Pharmaceut Anal Fuzhou 350122 Fujian Peoples R China;

    Fujian Med Univ Sch Pharm Dept Pharmaceut Anal Fuzhou 350122 Fujian Peoples R China;

    Fujian Med Univ Sch Pharm Dept Pharmaceut Anal Fuzhou 350122 Fujian Peoples R China;

    Fujian Med Univ Sch Pharm Dept Pharmaceut Anal Fuzhou 350122 Fujian Peoples R China;

    Fujian Med Univ Sch Pharm Dept Pharmaceut Anal Fuzhou 350122 Fujian Peoples R China;

    Fujian Med Univ Sch Pharm Dept Pharmaceut Anal Fuzhou 350122 Fujian Peoples R China;

    Fujian Med Univ Sch Pharm Dept Pharmaceut Anal Fuzhou 350122 Fujian Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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