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A study on graphene composites for peripheral nerve injury repair under electrical stimulation

机译:电刺激下外周神经损伤修复的石墨烯复合材料

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Electrical stimulation (ES) provides an effective alternative to peripheral nerve repair via conductive scaffolds. The aim of the present study is to investigate a graphene (GR)/thermoplastic polyurethane (TPU) composite for the repair of peripheral nerve injury under ES. To this end, conductive composite membranes were fabricated by blending GR (2, 4 and 6 wt%) with TPU. GR maintains its own structure in the composite and enhances the mechanical and electrical properties of the composite. The composites with excellent biocompatibility had a hemolysis rate of less than 5%. As a result, the 4GR-TPU (4 wt% GR) sample with enhanced mechanical properties possessed the highest conductivity value of 33.45 +/- 0.78 S m(-1). Compared with the non-conductive sample, 4GR-TPU was favorable for the viability of Schwann cells (SCs) under ES. When different voltages of ES were applied, a direct current of 10 mV was more suitable for the growth and proliferation of SCs. This study provides beneficial information for peripheral nerve repair via ES.
机译:电刺激(ES)通过导电支架提供了外周神经修复的有效替代方案。本研究的目的是研究石墨烯(GR)/热塑性聚氨酯(TPU)复合材料,用于修复ES下周围神经损伤。为此,通过用TPU混合GR(2,4和6wt%)来制造导电复合膜。 GR在复合材料中保持自己的结构,并增强复合材料的机械和电性能。具有优异的生物相容性的复合材料具有小于5%的溶血率。结果,具有增强的机械性能的4gR-TPU(4wt%GR)样品具有33.45 +/- 0.78 s m(-1)的最高电导率值。与非导电样品相比,4GR-TPU有利于谢旺细胞(SCS)根据ES下的活力。当施用ES的不同电压时,10mV的直流电流更适合于SC的生长和增殖。本研究为通过ES提供了外周神经修复的有益信息。

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    《RSC Advances》 |2019年第49期|共9页
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  • 正文语种 eng
  • 中图分类 化学;
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