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Preparation of terpolymer capsules containing Rosmarinus officinalis essential oil and evaluation of its antifungal activity

机译：含有Rosmarinus Officinalis精油的三元共聚物胶囊的制备和其抗真菌活性的评价

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摘要

The essential oil from Rosmarinus officinalis presents antifungal activity and is used in industry as a natural preserving agent. However, essential oils are unstable compounds. So, the encapsulation of essential oils is a technique used to protect it, minimizing degradation and reducing undesired interaction with the other formulation components. Thus, this work focuses on the synthesis of terpolymeric capsules containing essential oil from Rosmarinus officinalis, aiming to use it as an antifungal component in cosmetics. The capsules were obtained via terpolymerization of methyl methacrylate, styrene and methacrylic acid in a dispersed phase polymerization process. The properties of the polymers and the fungicide activity were evaluated. The studied essential oil presented a Minimum Inhibitory Concentration (MIC) ranging from 2.25 to 4.5 mg mL(-1) and a Minimum Fungicidal Concentration (MFC) from 4.5 to 9.0 mg mL(-1) for strains of Candida albicans, Candida glabrata and Candida parapsilosis, and after the encapsulation process, the antifungal activity of the oil was maintained. Additionally, cytotoxicity assays against fibroblast cell lines and human keratinocytes showed that the polymeric nanocapsules containing Rosmarinus officinalis essential oil can be regarded as a very promising material intended for cosmetics and drug delivery applications.
机译：来自Rosmarinus Officinalis的精油提出了抗真菌活性，并用于工业作为天然保存剂。然而，精油是不稳定的化合物。因此，精油的封装是用于保护它的技术，最小化降解和降低与其他配方组分的不希望的相互作用。因此，该工作侧重于合成含有来自Rosmarinus Officinalis的必需油的三聚物胶囊，旨在将其用作化妆品中的抗真菌组分。通过在分散相聚合过程中通过甲基丙烯酸甲酯，苯乙烯和甲基丙烯酸的三聚合而获得胶囊。评价聚合物和杀真菌剂活性的性质。所研究的精油呈现了从2.25至4.5mg ml（-1）的最小抑制浓度（MIC），以及4.5至9.0mg ml（-1）的最小杀菌浓度（MFC），用于念珠菌蛋白，念珠菌，念珠菌和Candida Parapsilosis和封装过程后，保持油的抗真菌活性。另外，对成纤维细胞系和人角蛋白细胞的细胞毒性测定表明，含有Rosmarinus Officinalis精油的聚合物纳米胶囊可以被认为是用于化妆品和药物递送应用的非常有前途的材料。

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  • 来源
    《RSC Advances》 |2019年第39期|共11页
  • 作者

    Neves Juliete Silva; Lopes-da-Silva Zita; Brito Neta Maria de Sousa; Chaves Sacha Braun; de Medeiros Nobrega Yanna Karla; de Lira Machado Angelo Henrique; Machado Fabricio;

  • 作者单位

    Univ Brasilia Inst Quim Campus Univ Darcy Ribeiro BR-70910900 Brasilia DF Brazil;

    Univ Brasilia Fac Ciencias Saude Campus Univ Darcy Ribeiro BR-70910900 Brasilia DF Brazil;

    Univ Brasilia Inst Biol Dept Genet &

    Morfol Campus Univ Darcy Ribeiro BR-70910900 Brasilia DF Brazil;

    Univ Brasilia Inst Biol Dept Genet &

    Morfol Campus Univ Darcy Ribeiro BR-70910900 Brasilia DF Brazil;

    Univ Brasilia Fac Ciencias Saude Campus Univ Darcy Ribeiro BR-70910900 Brasilia DF Brazil;

    Univ Brasilia Inst Quim Campus Univ Darcy Ribeiro BR-70910900 Brasilia DF Brazil;

    Univ Brasilia Inst Quim Campus Univ Darcy Ribeiro BR-70910900 Brasilia DF Brazil;

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  • 正文语种 eng
  • 中图分类 化学;
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