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Bright, near infrared emitting PLGA-PEG dye-doped CN-PPV nanoparticles for imaging applications

机译：明亮，近红外线发射PLGA-PEG染料掺杂CN-PPV纳米粒子用于成像应用

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摘要

Conjugated polymers are of interest as optical imaging probes for clinical diagnostic applications. However, clinical translation requires not only an excellent optical performance, but also an established safety profile and scalable manufacturability. Taking these factors into account, a self-assembling nanoparticle system was designed utilising the amphiphilic diblock copolymer, PLGA-PEG, to encapsulate the red-emitting conjugated polymer, CN-PPV. Encapsulation of decreasing amounts of CN-PPV (50% to 5% w/w) resulted in a decrease in nanoparticle size and an increase in optical performance (quantum yield% similar to 40%). All systems were colloidally and optically stable over 60 days at 37 degrees C. Optimized systems were then used to encapsulate small amounts (0.5-0.8% w/w) of small molecule near-infrared dyes, NIR680 and NIR720, generating systems with shifted emission peaks > 700 nm. Optimised PLGA-PEG micelles containing 5% CN-PPV and 0.5% NIR720 showed enhanced characteristics, such as a high product yield (> 90%), a narrow emission peak at 720 nm, a high quantum yield of 45%, a small hydrodynamic diameter (similar to 104 nm), and an enhanced cytocompatibility profile compared to other systems tested in this study, i.e. no reduction in cell viability and negligible impairment of mitochondrial acitivity at higher concentrations.
机译：共轭聚合物是临床诊断应用的光学成像探针的感兴趣。然而，临床翻译不仅需要出色的光学性能，而且需要建立的安全型材和可扩展的可制造性。考虑到这些因素，利用两亲二嵌段共聚物，PLGA-PEG设计自组装纳米粒子系统，以包封红发共轭聚合物CN-PPV。 CN-PPV的减少量（50％至5％w / w）的包封导致纳米颗粒尺寸的降低和光学性能的增加（量子产率％，与40％相似）。在37摄氏度的37℃下，所有系统在60天内致胶体和光学稳定。然后使用优化的系统来包封少量（0.5-0.8％w / w）的小分子近红外染料，NIR680和NIR720，产生具有变速发射的系统峰值> 700 nm。含有5％CN-PPV和0.5％NIR720的优化PLGA-PEG胶束显示出增强的特性，例如高产率（> 90％），窄排放峰值为720nm，高量子产率为45％，小流体动力学直径（类似于104nm），与该研究中测试的其他系统相比，即相比的增强的细胞膜相容性，即在较高浓度下不能降低细胞存活率和线粒体梭菌的损害。

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  • 来源
    《RSC Advances》 |2017年第25期|共10页
  • 作者

    Kemal Evren; Abelha Thais Fedatto; Urbano Laura; Peters Ruby; Owen Dylan M.; Howes P.; Green Mark; Dailey Lea Ann;

  • 作者单位

    Kings Coll London Dept Phys Strand Campus London WC2R 2LS England;

    Kings Coll London Inst Pharmaceut Sci Waterloo Campus London SE1 9NH England;

    Kings Coll London Inst Pharmaceut Sci Waterloo Campus London SE1 9NH England;

    Kings Coll London Dept Phys Strand Campus London WC2R 2LS England;

    Kings Coll London Dept Phys Strand Campus London WC2R 2LS England;

    Kings Coll London Dept Phys Strand Campus London WC2R 2LS England;

    Kings Coll London Dept Phys Strand Campus London WC2R 2LS England;

    Kings Coll London Inst Pharmaceut Sci Waterloo Campus London SE1 9NH England;

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  • 正文语种 eng
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