Synthesis of 1,2-disubstituted benzimidazoles using an aza-Wittig-equivalent process

Chen Yuan; Xu Fanghui; Sun Zhihua

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Synthesis of 1,2-disubstituted benzimidazoles using an aza-Wittig-equivalent process

机译：使用AZA-Wittig - 等效方法合成1,2-二取代的苯并咪唑

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A synthetic approach for 1,2-disubstituted benzimidazoles has been successfully designed based on effective C-N bond construction, which demonstrated mild reaction conditions and excellent yields. The method involves treating derivatives of o-phenylenediamine with tert-butanesulfoxide and NBS under acidic conditions, which undergoes an aza-Wittig-equivalent process to afford the desired products. Using this method, a series of benzimidazoles containing multiple functional groups with varying electronic effects have been successfully constructed.

机译：基于有效的C-N键结构成功设计了1,2-二取代的苯并咪唑的合成方法，其表现出轻度反应条件和优异的产率。该方法涉及将O-苯二胺的衍生物用叔丁沙砜和NBS处理酸性条件下，该方法经历AZA-Wittig - 等效方法，得到所需产物。使用这种方法，已经成功地建立了一系列包含具有不同电子效应的多个功能组的苯并咪唑。

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《RSC Advances》 |2017年第70期|共5页
作者
Chen Yuan; Xu Fanghui; Sun Zhihua;
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Shanghai Univ Engn Sci Coll Chem &

Chem Engn 333 Longteng Rd Shanghai 201620 Peoples R China;

Shanghai Univ Engn Sci Coll Chem &

Chem Engn 333 Longteng Rd Shanghai 201620 Peoples R China;

Shanghai Univ Engn Sci Coll Chem &

Chem Engn 333 Longteng Rd Shanghai 201620 Peoples R China;

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正文语种 eng
中图分类化学;
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1. Synthesis of 1,2-disubstituted benzimidazoles using an aza-Wittig-equivalent process [J] . Chen Yuan, Xu Fanghui, Sun Zhihua RSC Advances . 2017,第70期

机译：使用AZA-Wittig - 等效方法合成1,2-二取代的苯并咪唑
2. Synthesis of 1,2-disubstituted benzimidazoles using an aza-Wittig-equivalent process [J] . Yuan Chen, Fanghui Xu, Zhihua Sun RSC Advances . 2017,第70期

机译：使用氮杂-维蒂希当量法合成1,2-二取代的苯并咪唑
3. Metal-free selective synthesis of 2-substituted benzimidazoles catalyzed by Bronsted acidic ionic liquid: Convenient access to one-pot synthesis of N-alkylated 1,2-disubstituted benzimidazoles [J] . Senapak Warapong, Saeeng Rungnapha, Jaratjaroonphong Jaray, Tetrahedron . 2019,第26期

机译：无金属选择性合成2-取代的苯并咪唑催化的铜酸性离子液体：方便进入N-烷基化1,2-二取代苯并咪唑的单罐合成
4. Selective Synthesis of 2-Substityted and 1,2-Disubstituted Benzimidazoles [C] . Chengjun Wang, Shanshan Gong, Qi Sun International Conference on Material Engineering, Chemistry, Bioinformatics . 2014

机译：选择性合成2-Coffallated和1,2-二取代的苯并咪唑
5. A reiterative approach for the synthesis of the C(28)-C(20) fragment of rifamycin S polypropionate chain by the diastereoselective preparation and regioselective cleavage of oxiranes. Efficient and regioselective copper catalyzed alkenyl Grignard cleavage of 1,2-disubstituted epoxides [D] . Rodriguez Reyes, David 2006

机译：一种通过非对映选择性制备和区域选择性裂解环氧乙烷来合成利福霉素S聚丙烯酸酯链的C（28）-C（20）片段的迭代方法。高效和区域选择性铜催化的1,2-二取代环氧化物烯基格利雅裂解
6. Targeting Receptor Tyrosine Kinase VEGFR-2 in Hepatocellular Cancer: Rational Design Synthesis and Biological Evaluation of 12-Disubstituted Benzimidazoles [O] . Heba T. Abdel-Mohsen, Mona A. Abdullaziz, Ahmed M. El Kerdawy, 2020

机译：肝细胞癌中靶向受体酪氨酸激酶VEGFR-2：12-二取代苯并咪唑的合理设计合成和生物学评估
7. Synthesis of 1,2-disubstituted benzimidazoles using an aza-Wittig-equivalent process [O] . Yuan Chen, Fanghui Xu, Zhihua Sun 2017

机译：使用AZA-Wittig - 等效方法合成1,2-二取代的苯并咪唑
8. Organolithium Routes to 1,2-Disubstituted Ethylene Derivatives. An Attempted Synthesis of 1,2-Dilithioethylene. [R] . Seyferth, D., Vick, S. C. 1977

机译：有机锂路由到1,2-二取代乙烯衍生物。试图合成1,2-二硫代乙烯。

Synthesis of 1,2-disubstituted benzimidazoles using an aza-Wittig-equivalent process

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