• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Potentiation effect of HB-EGF on facilitating wound healing via 2-N, 6-O-sulfated chitosan nanoparticles modified PLGA scaffold
【24h】

Potentiation effect of HB-EGF on facilitating wound healing via 2-N, 6-O-sulfated chitosan nanoparticles modified PLGA scaffold

机译：HB-EGF对通过2-N，6-O-硫酸壳聚糖纳米粒子改性PLGA支架促进伤口愈合的增强作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Heparin-binding epidermal growth factor (HB-EGF) is of extreme importance for accelerating wound healing; however, its effective and controlled release remains to be solved. In this study, 2-N, 6-O-sulfated chitosan (26SCS), a highly sulfated polysaccharide, was utilized to fabricate delivery vehicles of HB-EGF encapsulated in PLGA nanofibers to achieve effective release. In addition, migration of Hacat cells was greatly promoted by 26SCS synergizing with HB-EGF released from the PLGA scaffold and proliferation was not affected. In a mouse excisional splinted model, a wound treated with HB-EGF loaded S-PLGA nanofibers was basically healed at 14 days. Conversely, wounds in other groups, including HB-EGF-loaded PLGA nanofibers, were not closured. The acceleration of wound healing was ascribed to the 26SCS-favored HB-EGF effect on the migration of keratinocyte which led to rapid reepithelialization. Furthermore, neovascularization was also observed in the HB-EGF loaded S-PLGA nanofiber treated wound. These data strongly proved that S-PLGA nanofibers with incorporated HB-EGF may provide a promising way for rapid regeneration of the cutaneous wounds.
机译：肝素结合表皮生长因子（HB-EGF）对于加速伤口愈合具有极端重要性;然而，其有效和控制的释放仍有待解决。在该研究中，利用2-N,6-O-硫酸壳聚糖（26SCS），高度硫酸化多糖，用于制造包封在PLGA纳米纤维中的HB-EGF的递送载体，以实现有效释放。此外，通过从PLGA支架释放的HB-EGF协同促进HaCAT细胞的迁移大大促进了HB-EGF，并且增殖不受影响。在小鼠切除夹板模型中，用Hb-EGF负载的S-PLGA纳米纤维处理的伤口基本上在14天后愈合。相反，在其他基团中的伤口，包括Hb-EGF加载的PLGA纳米纤维，未封闭。伤口愈合的加速度归因于对角蛋白细胞迁移的26岁的HB-EGF效应，这导致了快速再热量化。此外，在Hb-EGF负载的S-PLGA纳米纤维处理的伤口中也观察到新血管化。这些数据强烈证明，具有掺入HB-EGF的S-PLGA纳米纤维可以为快速再生的皮肤伤口提供有希望的方式。

著录项

  • 来源
    《RSC Advances》 |2017年第68期|共11页
  • 作者

    Peng Xiang; Yu Yuanman; Wang Zihao; Zhang Xiaohui; Wang Jing; Liu Changsheng;

  • 作者单位

    East China Univ Sci &

    Technol Key Lab Ultrafine Mat Minist Educ Shanghai 200237 Peoples R China;

    East China Univ Sci &

    Technol Key Lab Ultrafine Mat Minist Educ Shanghai 200237 Peoples R China;

    East China Univ Sci &

    Technol Key Lab Ultrafine Mat Minist Educ Shanghai 200237 Peoples R China;

    East China Univ Sci &

    Technol Engn Res Ctr Biomed Mat Minist Educ Shanghai 200237 Peoples R China;

    East China Univ Sci &

    Technol Key Lab Ultrafine Mat Minist Educ Shanghai 200237 Peoples R China;

    East China Univ Sci &

    Technol Key Lab Ultrafine Mat Minist Educ Shanghai 200237 Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号