• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Different toxicity of cadmium telluride, silicon, and carbon nanomaterials against hemocytes in silkworm, Bombyx mori
【24h】

Different toxicity of cadmium telluride, silicon, and carbon nanomaterials against hemocytes in silkworm, Bombyx mori

机译：碲化镉，硅和碳纳米材料对蚕蚕的不同毒性，Bombyx Mori

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The biological toxicity of nanomaterials is a concern because they have many potential applications in biomedical fields. In this study, silkworm hemolymph was exposed to high-dose cadmium telluride quantum dots (CdTe QDs), citric-acid-nitrogen-doped carbon dots (C-NCDs), or silicon nanoparticles (SiNPs) and the differences in the immune responses and programmed cell death induced in hemocytes were compared. Changes in the expression of innate-immunity-related genes and the occurrence of hemocytes in the hemolymph indicated that the three types of nanomaterials entered several types of hemocytes by endocytosis, but their toxicity differed significantly. C-NCDs only induced autophagy in the hemocytes, whereas SiNPs induced both hemocyte autophagy and the simultaneous apoptosis of a large number of cells. CdTe QD exposure rapidly induced hemocyte apoptosis and necrosis. The mechanisms of hemocyte apoptosis induced by the different nanomaterials differed significantly. The apoptosis induced by CdTe QDs was dependent on the lysosomal apoptotic pathway, whereas SiNPs also used the endoplasmic reticulum apoptotic pathway. The autophagy and even apoptosis that appeared in the hemocytes after SiNP exposure quickly self-repaired, whereas the autophagy induced in hemocytes by C-NCD exposure persisted.
机译：纳米材料的生物毒性是一个问题，因为它们在生物医学领域具有许多潜在的应用。在本研究中，蚕血淋巴暴露于高剂量碲化镉量子点（CdTe QD），柠檬酸 - 氮掺杂的碳点（C-NCD）或硅纳米颗粒（SINP）和免疫反应的差异和比较了血细胞中诱导的编程细胞死亡。先天免疫相关基因表达的变化和血淋巴中血细胞的发生表明，三种类型的纳米材料通过内吞作用进入了几种类型的血细胞，但它们的毒性显着差异。 C-NCDS仅在血细胞中诱导自噬，而SINPS诱导血液细胞自噬和同时凋亡的大量细胞。 CDTE QD暴露迅速诱导血液细胞凋亡和坏死。不同纳米材料诱导的血细胞凋亡的机制显着不同。 CDTE QD诱导的凋亡依赖于溶酶体凋亡途径，而SINPS也使用内质网凋亡途径。在SINP暴露后血细胞迅速自我修复后出现的自噬甚至凋亡，而C-NCD暴露的血细胞诱导的自噬持续存在。

著录项

  • 来源
    《RSC Advances》 |2017年第79期|共11页
  • 作者

    Li Kai-Le; Zhang Yun-Hu; Xing Rui; Zhou Yan-Feng; Chen Xue-Dong; Wang Hao; Song Bin; Sima Yang-Hu; He Yao; Xu Shi-Qing;

  • 作者单位

    Soochow Univ Med Coll Sch Biol &

    Basic Med Sci Suzhou 215123 Peoples R China;

    Soochow Univ Med Coll Sch Biol &

    Basic Med Sci Suzhou 215123 Peoples R China;

    Soochow Univ Med Coll Sch Biol &

    Basic Med Sci Suzhou 215123 Peoples R China;

    Soochow Univ Collaborat Innovat Ctr Suzhou Nano Sci &

    Technol Inst Funct Nano &

    Soft Mat FUNSOM Jiangsu Key Lab Carbon Based Funct Mat &

    Devices Suzhou 215123 Peoples R China;

    Soochow Univ Med Coll Sch Biol &

    Basic Med Sci Suzhou 215123 Peoples R China;

    Soochow Univ Collaborat Innovat Ctr Suzhou Nano Sci &

    Technol Soochow Inst Energy &

    Mat Innovat Coll Phys Optoelect &

    Energy Suzhou 215006 Peoples R China;

    Soochow Univ Collaborat Innovat Ctr Suzhou Nano Sci &

    Technol Inst Funct Nano &

    Soft Mat FUNSOM Jiangsu Key Lab Carbon Based Funct Mat &

    Devices Suzhou 215123 Peoples R China;

    Soochow Univ Med Coll Sch Biol &

    Basic Med Sci Suzhou 215123 Peoples R China;

    Soochow Univ Collaborat Innovat Ctr Suzhou Nano Sci &

    Technol Inst Funct Nano &

    Soft Mat FUNSOM Jiangsu Key Lab Carbon Based Funct Mat &

    Devices Suzhou 215123 Peoples R China;

    Soochow Univ Med Coll Sch Biol &

    Basic Med Sci Suzhou 215123 Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号