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首页> 外文期刊>RSC Advances >Antiviral and anti-inflammatory meroterpenoids: stachybonoids A-F from the crinoid-derived fungus Stachybotrys chartarum 952
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Antiviral and anti-inflammatory meroterpenoids: stachybonoids A-F from the crinoid-derived fungus Stachybotrys chartarum 952

机译：抗病毒和抗炎梅特萜类化合物：STOHNYBONOIODS A-F来自CRINOID-ertive真菌StachyBotrys Chartarum 952

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摘要

Six new meroterpenoids, which have been named as stachybonoids A-F (1-3 and 5-7), and three known phenylspirodrimanes (4, 8 and 9) were isolated from the crinoid-derived fungus Stachybotrys chartarum 952. Their structures were established on the basis of extensive spectroscopic data (1D and 2D NMR, MS, and ECD), as well as the modified Mosher's method and single-crystal X-ray structural analysis. Compound 1 exhibited inhibitory activity against the replication of dengue virus. Compounds 4, 7, and 8 exhibited moderate anti-inflammatory activity by inhibiting the production of nitric oxide (NO) in RAW264.7 cells activated by lipopolysaccharide, with IC50 values of 27.2, 52.5, and 17.9 mM, respectively.
机译：已被命名为Stachybonoids AF（1-3和5-7）和三种已知的苯基磺基二烷（4,8和9）的六种新的梅特萜类化合物与Crinop衍生的真菌Stachybotrys Captarum 952分离。它们的结构建立在 广泛的光谱数据（1D和2D NMR，MS和ECD）的基础，以及改进的Mosher方法和单晶X射线结构分析。 化合物1表现出抑制活性，以反对登革热病毒的复制。 化合物4,7和8通过抑制脂多糖激活的Raw264.7细胞中的一氧化氮（NO）的产生，分别具有27.2,52.5和17.9mm的IC 50值，表现出中等的抗炎活性。

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  • 来源
    《RSC Advances》 |2017年第79期|共7页
  • 作者

    Zhang Panpan; Li Yongfang; Jia Chunxiu; Lang Jiajia; Niaz Shah-Iram; Li Jing; Yuan Jie; Yu Jianchen; Chen Senhua; Liu Lan;

  • 作者单位

    Sun Yat Sen Univ Sch Marine Sci Guangzhou 510006 Guangdong Peoples R China;

    Sun Yat Sen Univ Sch Marine Sci Guangzhou 510006 Guangdong Peoples R China;

    Sun Yat Sen Univ Sch Chem Guangzhou 510275 Guangdong Peoples R China;

    Sun Yat Sen Univ Sch Chem Guangzhou 510275 Guangdong Peoples R China;

    Sun Yat Sen Univ Sch Marine Sci Guangzhou 510006 Guangdong Peoples R China;

    Sun Yat Sen Univ Sch Marine Sci Guangzhou 510006 Guangdong Peoples R China;

    Sun Yat Sen Univ Zhongshan Sch Med Guangzhou Guangdong Peoples R China;

    Sun Yat Sen Univ Zhongshan Sch Med Guangzhou Guangdong Peoples R China;

    Sun Yat Sen Univ Sch Marine Sci Guangzhou 510006 Guangdong Peoples R China;

    Sun Yat Sen Univ Sch Marine Sci Guangzhou 510006 Guangdong Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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