Transformable protein-gold hybrid materials serve as supramolecular vehicles for gene delivery

Li Zhenhua; Ding Han; Yan Fei; Li Hongwei; Chen Zhijun

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Transformable protein-gold hybrid materials serve as supramolecular vehicles for gene delivery

机译：可转化的蛋白质 - 金杂化材料用作基因递送的超分子载体

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Functional DNA cannot pass through plasma membrane of living cells by itself. An efficient non-viral DNA carrier with low cytotoxicity and simple preparation procedure is in high demand. Herein, we describe that protein-gold hybrid nanocubes (PGHNs) could intrinsically recognize DNAs, and transform them into nanoflower-like structures. These supramolecular complexes can be internalized by living yeast cells and allow the coding information of the gene to be transmitted into proteins. PGHN-DNA can be a good model to study DNA-carrier interactions as well as a new carrier for gene delivery research.

机译：功能性DNA本身不能通过活细胞的质膜。具有低细胞毒性和简单制备程序的有效的非病毒DNA载体具有很高的需求。在此，我们描述了蛋白质 - 金杂化纳米尺（PGHN）可以本质上识别DNA，并将它们转化为纳米闪光的结构。这些超分子复合物可以通过活酵母细胞内化并允许将基因的编码信息传递给蛋白质。 PGHN-DNA可以是研究DNA - 载体相互作用以及基因递送研究的新载体的良好模型。

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《RSC Advances》 |2017年第81期|共5页
作者
Li Zhenhua; Ding Han; Yan Fei; Li Hongwei; Chen Zhijun;
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Jilin Univ Inst Theoret Chem State Key Lab Supramol Struct &

Mat Int Joint Res Lab NanoMicro Architecture Chem 2699 Qianjin St Changchun 130012 Jilin Peoples R China;

Jilin Univ Inst Theoret Chem State Key Lab Supramol Struct &

Mat Int Joint Res Lab NanoMicro Architecture Chem 2699 Qianjin St Changchun 130012 Jilin Peoples R China;

Jilin Univ Inst Theoret Chem State Key Lab Supramol Struct &

Mat Int Joint Res Lab NanoMicro Architecture Chem 2699 Qianjin St Changchun 130012 Jilin Peoples R China;

Jilin Univ Inst Theoret Chem State Key Lab Supramol Struct &

Mat Int Joint Res Lab NanoMicro Architecture Chem 2699 Qianjin St Changchun 130012 Jilin Peoples R China;

Jilin Univ Inst Theoret Chem State Key Lab Supramol Struct &

Mat Int Joint Res Lab NanoMicro Architecture Chem 2699 Qianjin St Changchun 130012 Jilin Peoples R China;

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正文语种 eng
中图分类化学;
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1. Transformable protein-gold hybrid materials serve as supramolecular vehicles for gene delivery [J] . Li Zhenhua, Ding Han, Yan Fei, RSC Advances . 2017,第81期

机译：可转化的蛋白质 - 金杂化材料用作基因递送的超分子载体
2. Transformable protein–gold hybrid materials serve as supramolecular vehicles for gene delivery [J] . Zhenhua Li, Han Ding, Fei Yan, RSC Advances . 2017,第81期

机译：可转化的蛋白质-金杂化材料充当基因传递的超分子载体
3. Transformable protein–gold hybrid materials serve as supramolecular vehicles for gene delivery [J] . Zhenhua Li, Han Ding, Fei Yan, RSC Advances . 2017,第81期

机译：可转化的蛋白质-金杂化材料充当基因传递的超分子载体
4. SUPRAMOLECULAR POLYMERIC BIOMATERIALS FOR DRUG AND GENE DELIVERY [C] . Jun Li 5th International Symposium on High-Tech Polymer Materials（HTPM-V）（第五届国际高技术高分子材料学术会议）论文集 . 2008

机译：用于药物和基因转运的超分子聚合物生物材料
5. Applying Supramolecular Chemistry to the Synthesis and Characterization of Uranium Bearing Hybrid Materials. [D] . Deifel, Nicholas P. 2014

机译：超分子化学在含铀杂化材料的合成与表征中的应用。
6. Multifunctional Supramolecular Hybrid Materials Constructed from Hierarchical Self-Ordering of In Situ Generated Metal-Organic Framework (MOF) Nanoparticles [O] . Abhijeet K Chaudhari, Intaek Han, Jin-Chong Tan -1

机译：从原位生成的金属有机骨架（MOF）纳米粒子的分层自排序构造的多功能超分子杂化材料。
7. Transformable protein–gold hybrid materials serve as supramolecular vehicles for gene delivery [O] . Zhenhua Li, Han Ding, Fei Yan, 2017

机译：可转化的蛋白质 - 金杂化材料用作基因递送的超分子载体
8. Assembling a Lasing Hybrid Material With Supramolecular Polymers and Nanocrystals [R] . Li, L. , Beniash, E. , Zubarev, E. R. , 2003

机译：用超分子聚合物和纳米晶组装激光混合材料

Transformable protein-gold hybrid materials serve as supramolecular vehicles for gene delivery

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