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Technological advances in current metabolomics and its application in tradition Chinese medicine

机译：目前代谢组织技术进步及其在传统中医的应用

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摘要

During the last few years, many metabolomics technologies have been established in biomedical research for analyzing the changes of metabolite levels. They have also become important tools in the field of life sciences and are widely applied to discover innovative drugs, providing valuable methods to explore the function and essence of formulas in traditional Chinese medicine (TCM) research. Metabolomics shows major potential to provide a unique perspective for disease diagnosis and elucidate the action mechanism of TCM by measuring endogenous metabolites in biofluids. With the gradual expansion of the application fields of metabolomics, the related number of techniques is increasing day by day. The techniques of choice for the study of various low-molecular-weight metabolic pathways, and for the analysis of metabolites in search of the changes of biomarkers in TCM treatment of disease in biological samples include nuclear magnetic resonance (NMR) spectroscopy, chromatography coupled with mass spectrometry, and so forth. These techniques have been proven to be powerful tools for the detection of metabolites and biomarkers. Here, we will introduce the newly used analytical techniques for metabolomics, and metabolomics in TCM is also summarized.
机译：在过去几年中，已经在生物医学研究中建立了许多代谢组科技术，用于分析代谢物水平的变化。他们还成为生命科学领域的重要工具，并广泛应用于发现创新药物，提供有价值的方法来探讨中医（中医）研究中公式的功能和本质。代谢组虫显示出为疾病诊断提供独特的视角，并通过测量生物流体中的内源代谢物来阐明中医的作用机制。随着代谢组合的应用领域的逐步扩展，相关的技术数量日益增加。研究各种低分子量代谢途径的选择的技术，以及用于寻找生物样品中医治疗中医治疗中生物标志物变化的代谢物的分析包括核磁共振（NMR）光谱，色谱耦合质谱，等等。已经证明这些技术是检测代谢物和生物标志物的强大工具。在这里，我们将介绍新使用的代谢组科的分析技术，并且还总结了中医的代谢组学。

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  • 来源
    《RSC Advances》 |2017年第84期|共9页
  • 作者

    Song Qi; Zhang Ai-hua; Yan Guang-li; Liu Liang; Wang Xi-jun;

  • 作者单位

    Heilongjiang Univ Chinese Med Natl TCM Key Lab Serum Pharmacochem Sinoamer Chinmed Technol Collaborat Ctr Lab Metab Dept Pharmaceut Anal Chinmed Res Ctr State Adm TC Heping Rd 24 Harbin Heilongjiang Peoples R China;

    Heilongjiang Univ Chinese Med Natl TCM Key Lab Serum Pharmacochem Sinoamer Chinmed Technol Collaborat Ctr Lab Metab Dept Pharmaceut Anal Chinmed Res Ctr State Adm TC Heping Rd 24 Harbin Heilongjiang Peoples R China;

    Heilongjiang Univ Chinese Med Natl TCM Key Lab Serum Pharmacochem Sinoamer Chinmed Technol Collaborat Ctr Lab Metab Dept Pharmaceut Anal Chinmed Res Ctr State Adm TC Heping Rd 24 Harbin Heilongjiang Peoples R China;

    Macau Univ Sci &

    Technol State Key Lab Qual Res Chinese Med Ave Wai Long Taipa Macau Peoples R China;

    Heilongjiang Univ Chinese Med Natl TCM Key Lab Serum Pharmacochem Sinoamer Chinmed Technol Collaborat Ctr Lab Metab Dept Pharmaceut Anal Chinmed Res Ctr State Adm TC Heping Rd 24 Harbin Heilongjiang Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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