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Poly(anhydride) nanoparticles act as effective adjuvants to elicit a persistent immune response

机译：聚（酸酐）纳米颗粒充当有效的佐剂，以引发持续的免疫反应

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摘要

In order to evoke an efficient immune response to prevent and eliminate infectious and malignant diseases, it is critical to develop more effective and safer vaccines or adjuvants to enhance the antigenicity of natural antigens. The objective of this study is to produce nanoparticles composed of poly(methyl vinyl ether-co-maleic anhydride) (PVM/MA) and the model antigen ovalbumin (OVA), termed as p-OVAs, to assess the antigen sustained release property and the effectiveness in the immune responses in BALB/c mice. The results showed that the p-OVAs were spherical, evenly distributed with an average diameter of similar to 290 nm, and had a sustained release property in vitro. After immunization of BALB/C mice with p-OVA, strong OVA-specific cellular and humoral immune responses were observed in vivo. The whole blood cell tests and histological results also suggested that immunization with p-OVA is both effective and relatively safe. Overall, here we provide new insight into future vaccine and/or adjuvant design with PVM/MA, which is promising for the immunotherapy of cancer and autoimmune diseases.
机译：为了引起有效的免疫应答，以预防和消除传染病和恶性疾病，为提高天然抗原的抗原性而开发更有效和更安全的疫苗或佐剂至关重要。本研究的目的是生产由聚（甲基乙烯基醚 - 二氧化马来酸酐）（PVM / MA）和称为P-OVAS的模型抗原卵蛋白（OVA）组成的纳米颗粒，以评估抗原持续释放性能BALB / C小鼠免疫应答的有效性。结果表明，P-OVA是球形的，均匀分布，平均直径与290nm相似，并在体外具有持续的释放性。在用P-OVA的BALB / C小鼠免疫后，在体内观察到强大的卵巢特异性细胞和体液免疫应答。整个血细胞试验和组织学结果也表明用p-OVA免疫既有效又安全。总体而言，在这里，我们为未来疫苗和/或佐剂设计提供了新的PVM / MA，这对癌症和自身免疫疾病的免疫疗法有前途。

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