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首页> 外文期刊>RSC Advances >Investigation of a halloysite-based fluorescence probe with a highly selective and sensitive 'turn-on' response upon hydrogen peroxide
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Investigation of a halloysite-based fluorescence probe with a highly selective and sensitive 'turn-on' response upon hydrogen peroxide

机译：用过氧化氢高选择性和敏感的“开启”反应研究基于卤素基荧光探针的研究

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摘要

Inorganic halloysite nanotubes (HNTs) were modified with an organic fluorescein derivative (PA) to prepare HNTs-based hybrid fluorescence probe (HNTs-PA). Thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), solid-state C-13 NMR spectroscopy, X-ray photoelectron spectroscopy (XPS), energy dispersive spectrum (EDS) and transmission electron microscopy (TEM) confirmed that PA was successfully grafted onto the lumen of HNTs to obtain HNTs-PA with a grafting degree of 6.0%. The established B-C bond endows a selective fluorescence response toward hydrogen peroxide (H2O2) to HNTs-PA. The new hybrid probe exhibited a highly specific "turn-on" fluorescence response to H2O2 over other reactive oxygen species (ROS) and common ions owing to their chemoselective boronate-to-phenol switch. The "turn-on" response could even be tracked when the additional amount of H2O2 was limited to 1 x 10(-7) mol. Moreover, human lung cancer cells (A549 cells) were successfully stained and the staining intensity enhanced as time prolongs, which can be due to the overexpressed H2O2 of cancer cells. Thus, the as-prepared organic-inorganic hybrid fluorescence probe can have a broad range of applications for identification and diagnosis.
机译：用有机荧光素衍生物（PA）改性无机霍罗伊钛矿纳米管（HNT）以制备基于HNT的杂交荧光探针（HNTS-PA）。热重分析（TGA），傅里叶变换红外光谱（FTIR），固态C-13 NMR光谱，X射线光电子能谱（XPS），能量分散谱（EDS）和透射电子显微镜（TEM）证实了PA成功嫁接到HNT的内腔上，得到HNTS-PA，接枝度为6.0％。所建立的B-C键赋予过氧化氢（H 2 O 2）的选择性荧光反应至HNTS-PA。新的杂交探针由于其化学选择性硼酸硼酸盐切换而在其他活性氧物质（ROS）和常见离子上具有高度特异性的“开启”荧光反应。当额外量的H 2 O 2限制为1×10（-7）摩尔时，甚至可以跟踪“导通”响应。此外，人肺癌细胞（A549细胞）被成功染色，随着时间的推移，染色强度增强，这可能是由于癌细胞的过表达H2O2。因此，制备的有机无机杂交荧光探针可具有广泛的应用，用于鉴定和诊断。

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  • 来源
    《RSC Advances》 |2017年第87期|共7页
  • 作者

    Dong Jingwei; Zhao Zhihang; Liu Rui; Zhang Hailei; Wu Yonggang; Ba Xinwu;

  • 作者单位

    Hebei Univ Coll Chem &

    Environm Sci Baoding 071002 Hebei Peoples R China;

    Hebei Univ Coll Chem &

    Environm Sci Baoding 071002 Hebei Peoples R China;

    Hebei Univ Coll Chem &

    Environm Sci Baoding 071002 Hebei Peoples R China;

    Hebei Univ Coll Chem &

    Environm Sci Baoding 071002 Hebei Peoples R China;

    Hebei Univ Coll Chem &

    Environm Sci Baoding 071002 Hebei Peoples R China;

    Hebei Univ Coll Chem &

    Environm Sci Baoding 071002 Hebei Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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