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Dual-nozzle spray deposition process for improving the stability of proteins in polymer microneedles

机译：双喷嘴喷涂沉积工艺，用于提高聚合物微针中蛋白质稳定性

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摘要

Polymer microneedles are an attractive way of transdermal delivery of various pharmaceutical compounds. Fabrication of drug-encapsulating polymer microneedles, however, often involves processing conditions unfavorable for maintaining the stability of drugs, including highly concentrated formulations, high temperature and long drying time. The stability of labile substances in biodegradable polymer matrices could also be significantly reduced by the use of organic solvents and emulsification. In this paper, we reported a new fabrication technique called the dual-nozzle spray deposition process, which utilizes a separate deposition of drug and polymer solutions, as a potential way to address the stability issue associated with current microneedle fabrication processes. A model protein, bovine serum albumin (BSA), was successfully incorporated into both water-soluble poly(vinyl alcohol) (PVA) and biodegradable poly(lactic-co-glycolic acid) (PLGA) microneedles by the dual-nozzle spray deposition process. The conformational change of BSA examined by circular dichroism and fluorescence spectroscopy suggests that the developed process helps maintain the structural stability of BSA during encapsulation in both PVA and PLGA matrices. We anticipate that the dual-nozzle spray deposition process would improve the stability of drugs by reducing adverse interaction with solvents and eliminating the emulsification process. Also, the developed process could be an attractive approach to fabricating polymer-based drug delivery devices.
机译：聚合物微针是一种有吸引力的透皮递送各种药物化合物的方法。然而，制备药物包封的聚合物微针通常涉及对维持药物稳定性的加工条件，包括高度浓缩的制剂，高温和长干燥时间。通过使用有机溶剂和乳化也可以显着降低可生物降解聚合物基质中不稳定物质的稳定性。在本文中，我们报道了一种新的制造技术，称为双喷嘴喷射沉积过程，其利用药物和聚合物溶液的单独沉积，作为解决与当前微针制造工艺相关的稳定性问题的潜在方法。通过双喷嘴喷射沉积工艺成功地成功地掺入水溶性聚（乙烯醇）（PVA）和可生物降解的聚（乳酸 - 共乙醇酸）（PLGA）微作用中的模型蛋白质血清白蛋白（BSA） 。通过圆形二色性和荧光光谱检查BSA的构象变化表明，发育过程有助于在PVA和PLGA矩阵中的封装期间保持BSA的结构稳定性。我们预期双喷嘴喷雾沉积过程将通过降低溶剂的不利相互作用并消除乳化过程来提高药物的稳定性。而且，发育方法可以是制造聚合物的药物输送装置的吸引方法。

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  • 来源
    《RSC Advances》 |2017年第87期|共10页
  • 作者

    Kim Min Jung; Park Seok Chan; Choi Seong-O;

  • 作者单位

    Kansas State Univ Coll Vet Med Dept Anat &

    Physiol NICKS Manhattan KS 66506 USA;

    Kansas State Univ Coll Vet Med Dept Anat &

    Physiol NICKS Manhattan KS 66506 USA;

    Kansas State Univ Coll Vet Med Dept Anat &

    Physiol NICKS Manhattan KS 66506 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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