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首页> 外文期刊>Current medicinal chemistry. Anti-infective agents >Opportunities of Finding Novel Anti-Infective Agents from Plant Cell Cultures
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Opportunities of Finding Novel Anti-Infective Agents from Plant Cell Cultures

机译：从植物细胞培养物中发现新型抗感染剂的机会

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Higher plants have evolved into efficient biochemical defense mechanisms, which comprised of a wide variety of secondary compounds including alkaloids, flavonoids, terpenoids and saponins. Induction of secondary plant metabolism in cells, tissues and organ cultures do provide a potential alternative to the use of the whole plant or total synthesis of the active components, In vitro manipulation of plant secondary products offers biotechnological techniques to exploit cultured plant cell metabolism,In spite of the fact that very few plant cell processes are operating commercially, the most successful commercial Pharmaceuticals produced from undifferentiated cell cultures are antibiotic compounds The naphthoquinone shikonin from Lithospermum erythrorhizon is an anti-inflammatory, the isoquinoline alkaloid berberine from Coptis japonica is an intestinal antiseptic and the oral antimicrobial benzo-phenanthridine alkaloid sanguinarine from Papaver bracteatum are well known examples Moreover, intensive research studies is currently devoted to produce the anti-leukaemic alkaloids vinblastine and vincristine from Catharanthus roseus, the antimalaria artemisinin from Artemisia annua and the anti-ovarian cancer taxol from Taxus brevifolis The scope of this review is to analyze the successful in vitro production examples of antimicrobial agents, to give examples of novel chemical structures produced by plant cell cultures and not reported from the corresponding parent plants and to highlight the potential of biotransformation, elicitation and transformation techniques for the production of anti-infective agents from plant cell, tissue and organ cultures.
机译：高等植物已发展成为有效的生化防御机制，其由多种次级化合物组成，包括生物碱，类黄酮，萜类和皂苷。在细胞，组织和器官培养物中诱导次生植物代谢确实提供了使用全植物或活性成分全合成的潜在替代方法。对植物次生产物的体外操作提供了生物技术，以利用培养的植物细胞代谢，尽管几乎没有植物细胞过程在商业上运行，但未分化细胞培养物中生产的最成功的商业药物是抗生素化合物。来自紫草紫杉的萘醌紫草素是一种抗炎药，来自黄连的异喹啉生物碱小ber碱是一种肠杀菌剂。以及从罂粟属中获得的口服抗菌剂苯并菲啶生物碱血红碱碱是众所周知的例子。此外，目前正在进行深入的研究，以从长春花中提取抗白血病生物碱长春碱和长春新碱，从青蒿中提取抗疟疾青蒿素。 Nua和短叶红豆杉的抗卵巢癌紫杉醇本综述的范围是分析抗微生物剂的成功体外生产实例，提供由植物细胞培养物产生的新颖化学结构的实例，但未从相应的亲本植物中报道。强调生物转化，诱导和转化技术从植物细胞，组织和器官培养物中生产抗感染剂的潜力。

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