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首页> 外文期刊>Current medicinal chemistry. Anti-infective agents >Anti-Infective Action of Immuno-modulating Polysaccharides ((3-Glucan and Plantago Major L. Pectin) against Intracellular (Mycobacteria sp.) and Extracellular (Streptococcus Pneumoniae sp.) Respiratory Pathogens
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Anti-Infective Action of Immuno-modulating Polysaccharides ((3-Glucan and Plantago Major L. Pectin) against Intracellular (Mycobacteria sp.) and Extracellular (Streptococcus Pneumoniae sp.) Respiratory Pathogens

机译：免疫调节多糖（（3-葡聚糖和车前大果胶）对细胞内（分枝杆菌）和细胞外（肺炎链球菌）呼吸道病原菌的抗感染作用。

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The increasing occurrence of resistance to antibiotics among major respirator pathogens has become a public health threat calling for new therapeutics, beta-l,3-D-glucan is a polyglucose from yeast and moulds with known anti-infection and anti-tumor effects in rodent models. Recently, biologically active polysaccharides have also been isolated from Plantago major L, which has traditionally been used for wound healing. The aim of the current review is to examine whether stimulation of the host's immune system with such immuno-modulators could help the host combat infections with potentially harmful respiratory pathogens. Studies were performed with mice stimulated with beta-1,3-glucan or P. major polysaccharide and infected either with the intracellular pathogen Mycobacterium bovis, BCG, or the extracellular pathogen Streptococcus pneumoniae In addition, the effect of the agents on M tuberculosis-infected macrophages was examined in vitro, It was found that beta-glucans protected against M bovis, BCG and S. pneumoniae infections in vivo both when injected before and after challenge. Moreover, beta-glucans reduced growth of M tuberculosis in macrophage cultures, P. major L pectin polysaccharide did also protect against S pneumoniae infection in mice. The anti-infective action of P.. major L, pectin polysaccharide in mice was shown to be due to stimulation of the innate immune system, which is also the mechanism for the observed p-glucan effect. Thus, in the future, biologically active polysaccharides or other substances that stimulate the innate immune system, may prove to be useful alternative compounds in the fight against respiratory tract and other infections caused by multi-drug resistant pathogens,
机译：主要呼吸道病原体中对抗生素耐药性的日益增加已成为对公共卫生的威胁，需要新的治疗方法，β-1,3-D-葡聚糖是酵母和霉菌中的一种聚葡萄糖，在啮齿动物中具有已知的抗感染和抗肿瘤作用楷模。最近，还从车前子大车中分离了具有生物活性的多糖，该多糖传统上用于伤口愈合。本综述的目的是研究用这种免疫调节剂刺激宿主的免疫系统是否可以帮助宿主抵抗潜在有害的呼吸道病原体的感染。用受β-1,3-葡聚糖或P.major多糖刺激并感染了细胞内病原体牛分枝杆菌，BCG或细胞外病原体肺炎链球菌的小鼠进行了研究在体外检查了巨噬细胞。发现在攻击之前和之后注射时，β-葡聚糖在体内均对牛牛，卡介苗和肺炎链球菌感染具有保护作用。此外，β-葡聚糖减少了巨噬细胞培养物中结核分枝杆菌的生长，主要的体育果胶中的果胶多糖也确实可以防止小鼠感染肺炎链球菌。研究表明，大果李斯特果胶多糖在小鼠中的抗感染作用是由于先天免疫系统的刺激所致，这也是观察到的对β-葡聚糖作用的机制。因此，将来，具有生物活性的多糖或其他刺激先天免疫系统的物质可能被证明是对抗由多种药物引起的病原体引起的呼吸道和其他感染的有效替代化合物，

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