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首页> 外文期刊>Current medicinal chemistry. Anti-infective agents >Infectomics in the Discovery and Development of New Antimicrobial Agents
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Infectomics in the Discovery and Development of New Antimicrobial Agents

机译：发现和开发新的抗菌剂中的感染组学

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Infectious diseases are one of the leading causes of death in the world. This major medical concern is due to the continual emergence of new infectious diseases and reemergence of old pathogens, together with an increasing number of pathogens resistant to antimicrobial drugs. The generation of new anti-infective agents for resolving these medical problems has emerged as an urgent issue in modern medicine. The availability of genome sequences, and the development of various high-throughput techniques and computational tools offer holistic and integrative strategies for dissecting the interplay between microbial pathogens and their hosts (infectomics).Both microbial and host signatures of infectomes, which mirror the interplay between pathogens and their hosts, provide invaluable fountains in the search for novel antimicrobial therapies. There are several major issues in the discovery and development of new drugs, from target discovery and validation to animal models and clinical trials. However, infectomic approaches integrating genomics, proteomics and glycomics will become increasingly important. Essential Therapeutics Inc. has successfully used functional genomic methods to identify several hundred antimicrobial targets in representative bacterial, fungal and viral pathogens. Recent advances in chemical genomics and proteomics have revolutionized drug discovery research by allowing the parallel processing of multiple genomic targets against large numbers of diverse compounds, The identification of small-molecule modulators of biological functions that are usually executed by large molecules (DNAs, RNAs, proteins and polysaccharides), and the process of transforming these into high-content lead series, are key activities in modern drug discovery. This review focuses on infectomics and its applications to antimicrobial drug discovery.
机译：传染病是世界上主要的死亡原因之一。这种主要的医学问题是由于新的传染病的不断出现和旧病原体的再出现，以及对抗菌药物产生耐药性的病原体数量的增加。解决这些医学问题的新抗感染剂的产生已成为现代医学中的紧迫问题。基因组序列的可用性以及各种高通量技术和计算工具的发展为剖析微生物病原体与其宿主之间的相互作用（感染组学）提供了整体和整合的策略。病原体及其宿主，为寻找新的抗菌疗法提供了宝贵的泉源。从靶标的发现和验证到动物模型和临床试验，新药的发现和开发中存在几个主要问题。但是，整合基因组学，蛋白质组学和糖组学的传染组学方法将变得越来越重要。 Essential Therapeutics Inc.已成功使用功能基因组学方法来鉴定代表性细菌，真菌和病毒病原体中的数百种抗菌目标。化学基因组学和蛋白质组学的最新进展通过允许并行处理针对大量不同化合物的多个基因组靶标，彻底改变了药物发现研究。鉴定通常由大分子执行的生物学功能的小分子调节剂（DNA，RNA，蛋白质和多糖）以及将其转化为高含量先导系列的过程，是现代药物发现中的关键活动。这篇综述着重于感染组学及其在抗菌药物发现中的应用。

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