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首页> 外文期刊>Spectrochimica acta, Part A. Molecular and biomolecular spectroscopy >Novel feature extraction approach for achieving potential spectral resolution: Green analytical application on zofenopril calcium and hydrochlorothiazide in their spectrally overlapping binary mixture
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Novel feature extraction approach for achieving potential spectral resolution: Green analytical application on zofenopril calcium and hydrochlorothiazide in their spectrally overlapping binary mixture

机译：用于实现潜在光谱分辨率的新颖特征提取方法：唑唑钙钙和氢氯噻嗪在其光谱重叠二元混合物中的绿色分析施用

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摘要

A novel and green spectrophotometric method, namely constant extraction, based on extracting a spectral feature value (constant ratio) has been developed and validated for simultaneous estimation of a binary mixture of zofenopril calcium (ZOF) and hydrochlorothiazide (HCT) in their bulk and marketable formulation. A comparative study between this newly developed method and four long-established ones; ratio difference, ratio subtraction coupled with constant multiplication, advanced amplitude modulation and absorbance subtraction has been carried out giving very promising results. Various analytical performance parameters like linearity, accuracy, precision, and robustness were investigated in accordance with ICH (Q2B). Satisfying optimized instrumental parameters; absorbance of ZOF and HCT were linearly increased for the previously mentioned methods in a concentration range 5.0-35.0 and 3.0-20.0 mu g/mL, respectively showing correlation coefficients >= 0.9990. Moreover, specificity has been checked through analyzing synthetic mixtures of the studied analytes. Feasibility has been successfully assessed by simultaneous quantification of both analytes in the commercially available formulation. As well, validity was examined and no interference from common excipients was noticed. Observed data has been statistically compared with those of the published one concluding that no significant variations between both results have been indicated. Furthermore, greenness profile of these methods was assessed by analytical Eco-Scale and found superior to that of the reported HPLC method as an even greener approach for the simultaneous analysis of ZOF and HCT. (C) 2020 Elsevier B.V. All rights reserved.
机译：一种新的和绿色分光光度法，即恒定提取，基于提取光谱特征值（恒定比率），并验证以同时估计Zofenopril钙（ZOF）和盐酸盐（HCT）的二元混合物在散装和销售中公式。这种新开发方法与四个长期成熟的比较研究;比率差异，与恒定倍增耦合的比率减法，进行了高级幅度调制和吸光度减法，给出了非常有前途的结果。根据ICH（Q2B）研究了线性，准确性，精度和鲁棒性等各种分析性能参数。满足优化的仪器参数;对于先前提到的浓度范围5.0-35.0和3.0-20.0μmg/ ml的方法，ZOF和HCT的吸光度是线性增加的，分别显示相关系数> = 0.9990。此外，通过分析所研究的分析物的合成混合物来检查特异性。通过同时定量商业上可用的配方中的分析物同时定量可行性。同样，检查了有效性，没有注意到普通赋形剂的干扰。观察到的数据与已发表的结论的数据进行了统计数据，即已表明两种结果之间没有显着变化。此外，通过分析生态级评估这些方法的绿色谱，并发现报告的HPLC方法的均匀性均是更环保的方法，以获得ZOF和HCT的同时分析的均匀性方法。 （c）2020 Elsevier B.v.保留所有权利。

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