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首页> 外文期刊>Current Microbiology: An International Journal >Differential Immune Responses and Protective Effects in Avirulent Mycobacterial Strains Vaccinated BALB/c Mice
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Differential Immune Responses and Protective Effects in Avirulent Mycobacterial Strains Vaccinated BALB/c Mice

机译：无毒分枝杆菌疫苗接种的BALB / c小鼠的差异免疫反应和保护作用。

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摘要

Screening live mycobacterial vaccine candidates is the important strategy to develop new vaccines against adult tuberculosis (TB). In this study, the immunogenicity and protective efficacy of several avirulent mycobacterial strains including Mycobacterium smegmatis, M. vaccae, M. terrae, M. phlei, M. trivial, and M. tuberculosis H37Ra were compared with M. bovis BCG in BALB/c mice. Our results demonstrated that differential immune responses were induced in different mycobacterial species vaccinated mice. As BCG-vaccinated mice did, M. terrae immunization resulted in Th1-type responses in the lung, as well as splenocytes secreting IFN-gamma against a highly conserved mycobacterial antigen Ag85A. M. smegmatis also induced the same splenocytes secreting IFN-gamma as BCG and M. terrae did. In addition, M. terrae and M. smegmatis-immunized mice predominantly increased expression of IL-10 and TGF-beta in the lung. Most importantly, mice vaccinated with H37Ra and M. vaccae could provide the same protection in the lung against virulent M. tuberculosis challenge as BCG. The result may have important implications in developing adult TB vaccine.
机译：筛选活的分枝杆菌候选疫苗是开发针对成人结核病（TB）的新疫苗的重要策略。在这项研究中，比较了几种无毒分枝杆菌菌株（包括耻垢分枝杆菌，vaccae分枝杆菌，terra.M。phlei，M。trivial和结核分枝杆菌H37Ra）与牛分枝杆菌BCG在BALB / c中的免疫原性和保护功效。老鼠。我们的结果表明，在接种不同分枝杆菌的小鼠中诱导了不同的免疫应答。正如接种BCG的小鼠所做的那样，M.terrae免疫导致肺部Th1型反应，以及针对高度保守的分枝杆菌抗原Ag85A分泌IFN-γ的脾细胞。耻垢分枝杆菌还诱导出与BCG和terra.Mere相同的分泌IFN-γ的脾细胞。此外，T.terrae和耻垢分枝杆菌免疫的小鼠主要增加了肺中IL-10和TGF-β的表达。最重要的是，接种H37Ra和牛痘分枝杆菌的小鼠在肺部的抵抗力可能与BCG相同，可以抵抗结核分枝杆菌的侵袭。该结果可能对开发成人结核疫苗具有重要意义。

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