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首页> 外文期刊>Surgical Endoscopy >Safety and location analysis of transumbilical endoscopic submucosal dissection with single-basin lymph node dissection in the upper gastric body: a porcine model
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Safety and location analysis of transumbilical endoscopic submucosal dissection with single-basin lymph node dissection in the upper gastric body: a porcine model

机译：高盆地淋巴结清扫术的斜隙内窥镜粘膜粘膜粘膜粘膜安全性和定位分析：猪模型

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摘要

Background In our previous study, transumbilical endoscopic submucosal dissection (TU-ESD) was revealed to be feasible, but delayed gastric perforation was observed in 30% of ESD sites. In this study, we aimed to verify locations at which it is feasible to perform TU-ESD in the upper gastric body and to demonstrate the safety of TU-ESD in single-basin lymph node dissection (SBLND). Methods In vitro, TU-ESD was performed at three lesion sites (anterior wall, AW; posterior wall, PW; and lesser curvature, LC) in each porcine stomach using an EASIE-R tray (cases = 10). In vivo, TU-ESD was performed with SBLND in 9 pigs. Seven days after the operation, the pigs were sacrificed and examined. Results In the in vitro feasibility study, the TU-ESD time was significantly faster in the PW group (5.9 +/- 2.0 min) than in the LC group (8.5 +/- 1.5 min) (p < 0.05) in all 10 cases. In the in vivo survival study, TU-ESD with SBLND was successfully performed without any complications (N = 9). There were no cases of delayed perforation, and healing ulcers were found in all pigs 7 days after the operation. Ulcer size (5.2 +/- 3.5 cm(2)) was approximately 36% smaller than that observed at the ESD operation site (8.1 +/- 1.9 cm(2)) (p = 0.05). Epithelialization in the margin and healing of the gastric ulcers were confirmed by microscopy. Conclusions TU-ESD with SBLND is a feasible and safe method. The upper posterior gastric body could be the most feasible location for performing TU-ESD, perhaps because of the difference in the subcutaneous dissection time.
机译：背景在我们以前的研究，经脐内镜黏膜下剥离术（TU-ESD）显露是可行的，但推迟ESD网站30％的患者胃穿孔。在这项研究中，我们的目的是验证在该是可行的在上部胃体执行TU-ESD和证明TU-ESD在单盆淋巴结清扫（SBLND）的安全位置。使用项目EATCHIP-R盘（例= 10）在每个猪胃方法体外，TU-ESD是在三个病变部位（和小弯，LC;后壁，PW前壁，AW）进行。在体内，TU-ESD用SBLND 9对猪进行。手术后七天，猪处死并进行检查。结果在体外可行性研究中，TU-ESD时间显著的PW组（5.9±2.0分钟）在除LC组（8.5±1.5分钟）（P <0.05）在快于所有10案件。在体内存活研究中，TU-ESD与SBLND无任何并发症（N = 9）被成功执行。目前还没有推迟穿孔的情况下，以及在操作后7天所有的猪被发现溃疡愈合。溃疡大小（5.2±3.5厘米（2））比在所述ESD操作现场观察到更小的约36％（8.1±1.9厘米（2））（P = 0.05）。上皮的保证金和胃溃疡愈合通过显微镜证实。结论TU-ESD与SBLND是可行且安全的方法。上部后胃体可以是用于执行TU-ESD，也许是因为在皮下解剖时间差的最可行的位置。

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  • 来源
    《Surgical Endoscopy》 |2020年第2期|共8页
  • 作者

    Jeong Sang-Ho; Min Jae-Seok; Park Ji-Ho; Hong Soon-Chan; Jung Eun-Jung; Ju Young-Tae; Jeong Chi-Young; Lee Han Shin; Park Miyeong; Lee Young-Joon; Ha Chang Yoon;

  • 作者单位

    Gyeongsang Natl Univ Sch Med Dept Surg Gyeongsang Natl Univ Hosp 15 Jinju Daero 816 Beon Gil;

    Dongnam Inst Radiol &

    Med Sci Canc Ctr Dept Surg Busan South Korea;

    Gyeongsang Natl Univ Sch Med Dept Surg Gyeongsang Natl Univ Hosp 15 Jinju Daero 816 Beon Gil;

    Gyeongsang Natl Univ Sch Med Dept Surg Gyeongsang Natl Univ Hosp 15 Jinju Daero 816 Beon Gil;

    Gyeongsang Natl Univ Sch Med Dept Surg Gyeongsang Natl Univ Hosp 15 Jinju Daero 816 Beon Gil;

    Gyeongsang Natl Univ Sch Med Dept Surg Gyeongsang Natl Univ Hosp 15 Jinju Daero 816 Beon Gil;

    Gyeongsang Natl Univ Sch Med Dept Surg Gyeongsang Natl Univ Hosp 15 Jinju Daero 816 Beon Gil;

    Gyeongsang Natl Univ Sch Med Dept Surg Gyeongsang Natl Univ Hosp 15 Jinju Daero 816 Beon Gil;

    Gyeongsang Natl Univ Dept Anesthesiol Sch Med Jinju South Korea;

    Gyeongsang Natl Univ Sch Med Dept Surg Gyeongsang Natl Univ Hosp 15 Jinju Daero 816 Beon Gil;

    Gyeongsang Natl Univ Dept Internal Med Sch Med Jinju South Korea;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 诊断学;
  • 关键词

    Endoscopic submucosal dissection; Single-port surgery; Gastric neoplasm; Endoscope; Laparoscopy; Porcine;

    机译：内窥镜粘膜粘膜解剖;单港手术;胃肿瘤;内窥镜;腹腔镜;猪;

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