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首页> 外文期刊>Surgical Endoscopy >Long-term reported outcomes of transoral incisionless fundoplication: an 8-year cohort study
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Long-term reported outcomes of transoral incisionless fundoplication: an 8-year cohort study

机译：长期报告的传感器无故障原型的结果：8年的队列研究

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BackgroundTransoral incisionless fundoplication (TIF) offers an endoscopic approach to the treatment of gastroesophageal reflux disease (GERD). Controlled trials have demonstrated the short-term efficacy of this procedure, but long-term follow-up studies are lacking. The objective of this study was to evaluate the long-term impact of TIF on disease-specific quality of life and antisecretory medication use.MethodsWe performed retrospective cohort study of all patients undergoing TIF between 2007 and 2014 in a large academic medical center. Reflux symptoms and quality of life were assessed using the gastroesophageal reflux disease health-related quality of life (GERD-HRQL) questionnaire at baseline, short-term, and long-term follow-up.ResultsFifty-seven patients with a median age of 46 (37-59) years and an average BMI of 28.84.9kg/m(2) underwent TIF during the study period. Sixty percent of the patients were female, and all were taking a PPI at least daily. At a median follow-up interval of 97months, twelve patients had undergone subsequent laparoscopic antireflux surgery (LARS). Of those who had not, 23 had complete long-term follow-up data for analysis and were included in the study. Seventy-three percent reported daily acid-reducing medication use, and the median GERD-HRQL score was 10 (6-14) compared to 24 (15-28) at baseline (p<0.01). Seventy-eight percent of these patients expressed satisfaction or neutral feelings about their GERD management. There were no significant differences in the baseline characteristics of patients who underwent LARS during the study period and those who did not.Conclusions p id=Par4 This study demonstrates that TIF can produce durable improvements in disease-specific quality of life in some patients with symptomatic GERD. The majority of patients resumed daily PPI therapy during the study period, but with significantly improved GERD-HRQL scores compared to baseline and increased satisfaction with their medical condition.
机译：BackgroundTransoral Delientless Foogoplication（TIF）提供了一种内窥镜方法来治疗胃食管反流疾病（GERD）。受控试验表明了该程序的短期疗效，但缺乏长期的后续研究。本研究的目的是评估TIF对疾病特异性生活质量的长期影响和防治药物用途。乙二醇在大型学术医疗中心在2007年至2014年间接受TIF的所有患者进行了回顾性队列研究。利用胃食管反流疾病与基线，短期和长期随访的胃食管反流疾病患者相关质量（GERD-HRQL）问卷评估回流症状和生活质量。患者中位数为46岁的患者（37-59）年和平均BMI为28.84.9kg / m（2）在研究期间接受TIF。六十个患者是女性，所有人都至少每天服用PPI。在97个月的中位后续间隔，12名患者随后的腹腔镜抗反射手术（Lars）。其中没有，23的人有完整的长期随访数据进行分析，并被列入研究。百分之七十三个报告的每日酸还原药使用，中位数GERD-HRQL得分为10（6-14），而基线（P <0.01）。这些患者中有78％对其GERD管理层表示满意或中立的感受。在研究期间患者的患者的基线特征没有显着差异，那些没有的人.Clusions p id = par4这项研究表明，TIF在一些症状患者中可以产生疾病特异性生活质量的耐用性改善杰德。大多数患者在研究期间恢复了每日PPI治疗，但与基线相比，GERD-HRQL分数显着改善，并随着其医疗状况的满足而增加。

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