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首页> 外文期刊>Current molecular medicine >Therapeutic hypothermia as a neuroprotective strategy in neonatal hypoxic-ischemic brain injury and traumatic brain injury
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Therapeutic hypothermia as a neuroprotective strategy in neonatal hypoxic-ischemic brain injury and traumatic brain injury

机译：低温治疗作为新生儿缺氧缺血性脑损伤和创伤性脑损伤的神经保护策略

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摘要

Evidence shows that artificially lowering body and brain temperature can significantly reduce the deleterious effects of brain injury in both newborns and adults. Although the benefits of therapeutic hypothermia have long been known and applied clinically, the underlying molecular mechanisms have yet to be elucidated. Hypoxic-ischemic brain injury and traumatic brain injury both trigger a series of biochemical and molecular events that cause additional brain insult. Induction of therapeutic hypothermia seems to ameliorate the molecular cascade that culminates in neuronal damage. Hypothermia attenuates the toxicity produced by the initial injury that would normally produce reactive oxygen species, neurotransmitters, inflammatory mediators, and apoptosis. Experiments have been performed on various depths and levels of hypothermia to explore neuroprotection. This review summarizes what is currently known about the beneficial effects of therapeutic hypothermia in experimental models of neonatal hypoxic-ischemic brain injury and traumatic brain injury, and explores the molecular mechanisms that could become the targets of novel therapies. In addition, this review summarizes the clinical implications of therapeutic hypothermia in newborn hypoxic-ischemic encephalopathy and adult traumatic brain injury.
机译：有证据表明，人为地降低身体和大脑的温度可以显着降低新生儿和成年人的脑损伤的有害影响。尽管低温治疗的益处早已为人所知并已在临床上应用，但尚未阐明其潜在的分子机制。缺氧缺血性脑损伤和外伤性脑损伤均会引发一系列生化和分子事件，从而引起额外的脑损伤。诱导治疗性低温似乎可以改善最终导致神经元损伤的分子级联反应。体温过低会减弱初始损伤产生的毒性，这种损伤通常会产生活性氧，神经递质，炎症介质和细胞凋亡。已经针对低温的各种深度和水平进行了实验以探索神经保护作用。这篇综述总结了目前关于低温治疗在新生儿缺氧缺血性脑损伤和脑外伤实验模型中的有益作用的认识，并探讨了可能成为新疗法靶点的分子机制。此外，本综述总结了低温治疗在新生儿缺氧缺血性脑病和成人颅脑损伤中的临床意义。

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