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首页> 外文期刊>Pediatric blood & cancer >Second malignancies in patients treated for Ewing sarcoma: A systematic review
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Second malignancies in patients treated for Ewing sarcoma: A systematic review

机译:对育种肉瘤治疗的患者的第二个恶性肿瘤:系统审查

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摘要

Abstract The therapies used to treat Ewing sarcoma are associated with a risk of second malignant neoplasm (SMN). We conducted a systematic review to pool available evidence on the risks, types, and outcomes after SMN. We obtained 52 articles that met inclusion criteria. Cumulative incidence rates of SMN ranged from 0.9 to 8.4% and 10.1 to 20.5% at 5 and 30 years after initial diagnosis. Of the 327 reported SMNs, 63.6% were solid tumors, although acute myeloid leukemia /myelodysplastic syndrome was the single most commonly diagnosed SMN, with generally poor outcomes. Patients treated for Ewing sarcoma are at substantial risk of SMN, with a broad range of reported secondary cancers.
机译:摘要用于治疗EWING SARCOMA的疗法与第二个恶性肿瘤(SMN)的风险有关。 我们对SMN后的风险,类型和结果进行了系统审查,以汇集有关风险,类型和结果的证据。 我们获得了52篇符合纳入标准的文章。 初步诊断后5和30年,SMN的累积发病率范围为0.9%至8.4%,10.1%至20.5%。 在327张报告的SMN中,63.6%是实体瘤,虽然急性髓性白血病/髓细胞增生综合征是最常见的SMN,但常见的结果差。 为育龄肉瘤治疗的患者具有大量的SMN风险,具有广泛的报告的继发性癌症。

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